SCHEMBL14775397

SCHEMBL14775397

COC(=O)C1c2ccc(OCc3cccnc3C)cc2CCN1C(=O)OCC(C)C

nearest known ligand 0.48

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 19/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3069172 0.89 GHSR (0.51) GHSR
SCHEMBL3069134 0.87 GHSR (0.54) GHSR
SCHEMBL3062801 0.87 GHSR (0.51) GHSR
SCHEMBL3061545 0.87 GHSR (0.48) GHSR
SCHEMBL3074254 0.87 GHSR (0.48) GHSR
SCHEMBL13139194 0.87 GHSR (0.54) GHSR
SCHEMBL3067390 0.87 GHSR (0.52) GHSR
SCHEMBL3072628 0.87 GHSR (0.51) GHSR
SCHEMBL3066502 0.87 GHSR (0.51) GHSR
SCHEMBL3068014 0.86 GHSR (0.48) GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1951675-B1 TETRAHYDROISOQUINOLINE AS LXR MODULATORS BRISTOL MYERS SQUIBB CO (US) 2013-03-20 EP disclosed