Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.61 |
| ▸ | HPGD | P15428 | 9/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852678 | 0.93 | HTT (0.64) | HTTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL852752 | 0.89 | ALDH1A1 (0.65) | HTTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL853189 | 0.88 | ALDH1A1 (0.75) | HTTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL853789 | 0.84 | HTT (0.64) | HTTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL854227 | 0.83 | KDM4E (0.71) | HTTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL14775627 | 0.82 | PDE7A (0.63) | — | |
| SCHEMBL854762 | 0.80 | ALDH1A1 (0.67) | HTTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL853404 | 0.80 | HTT (0.84) | HTTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL853620 | 0.80 | ALDH1A1 (0.77) | HTTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL852703 | 0.80 | KDM4E (0.71) | HTTNPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1775298-B1 | THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY | DAIICHI SANKYO CO LTD (JP) | 2013-03-20 | — | — | EP | claimed |