Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL641724 | 0.90 | KDM4C (0.39) | KDM4CKDM6BBCL2MCL1EPHX1 | |
| SCHEMBL2513812 | 0.82 | MAOA (0.42) | KDM4CEPHX1 | |
| SCHEMBL10110763 | 0.78 | BCL2 (0.44) | KDM4CBCL2MCL1 | |
| SCHEMBL10110768 | 0.78 | HPGD (0.47) | KDM4CBCL2MCL1 | |
| SCHEMBL17361744 | 0.77 | KDM4C (0.36) | KDM4CKDM6BMGLLHAO1PARP10 | |
| SCHEMBL644016 | 0.77 | EPHX1 (0.36) | KDM4CEPHX1MGLLSLC6A9HAO1 | |
| SCHEMBL27856967 | 0.77 | KDM4C (0.37) | KDM4CKDM6BEPHX1MGLLSLC6A9 | |
| Hydrochloric Acid SCHEMBL30558475 | 0.76 | KDM4C (0.36) | KDM4CMGLLHAO1PARP10PARP11 | |
| SCHEMBL644307 | 0.76 | KDM4C (0.36) | KDM4CMGLLHAO1PARP10PARP11 | |
| SCHEMBL642086 | 0.72 | MAOA (0.54) | KDM4CPARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379491-B1 | Process for synthesis of amino-methyl tetraline derivatives | HOFFMANN LA ROCHE (CH) | 2013-03-20 | — | — | EP | disclosed |