Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14775765 | 0.92 | KCNH2 (0.64) | HDAC1KCNH2HDAC3HDAC2 | |
| SCHEMBL14775804 | 0.89 | HDAC1 (0.58) | HDAC1KCNH2HDAC3HDAC2 | |
| SCHEMBL14775987 | 0.87 | HDAC1 (0.63) | HDAC1HDAC3HDAC2 | |
| SCHEMBL14775970 | 0.86 | HDAC1 (0.62) | HDAC1HDAC3HDAC2 | |
| SCHEMBL14775799 | 0.86 | HDAC1 (0.56) | HDAC1KCNH2HDAC3HDAC2 | |
| SCHEMBL14775855 | 0.85 | HDAC1 (0.61) | HDAC1HDAC3HDAC2 | |
| SCHEMBL2686762 | 0.85 | HDAC1 (0.60) | HDAC1KCNH2HDAC3HDAC2 | |
| SCHEMBL14775896 | 0.85 | HDAC1 (0.70) | HDAC1HDAC2 | |
| SCHEMBL14775767 | 0.85 | HDAC1 (0.58) | HDAC1HDAC3HDAC2 | |
| SCHEMBL14775979 | 0.83 | HDAC1 (0.65) | HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991226-B1 | INHIBITORS OF HISTONE DEACETYLASE | MERCK SHARP & DOHME (US) | 2013-03-20 | — | — | EP | claimed |