Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100763 | 0.90 | NPC1 (0.48) | NPC1PKMRAB9APPARAAPEX1 | |
| SCHEMBL2684459 | 0.86 | NPC1 (0.52) | NPC1PKMRAB9APPARAAPEX1 | |
| SCHEMBL135445 | 0.85 | NPC1 (0.49) | NPC1PKMRAB9APPARAAPEX1 | |
| SCHEMBL2684347 | 0.79 | PPARA (0.56) | NPC1PKMRAB9APPARAAPEX1 | |
| SCHEMBL474201 | 0.76 | NPC1 (0.45) | NPC1PKMRAB9APPARAAPEX1 | |
| SCHEMBL173190 | 0.74 | NPC1 (0.44) | NPC1PKMRAB9APPARAAPEX1 | |
| SCHEMBL2684142 | 0.73 | NPC1 (0.55) | NPC1PKMRAB9AAPEX1SMN1; SMN2 | |
| SCHEMBL6946494 | 0.73 | NPC1 (0.49) | NPC1PKMRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6946491 | 0.73 | NPC1 (0.49) | NPC1PKMRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL474209 | 0.72 | CACNA1B (0.45) | ALDH1A1HPGDGAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205593-B1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-01-13 | — | — | EP | disclosed |
| EP-2416777-B1 | THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES | SANOFI SA (FR) | 2014-11-12 | — | — | EP | disclosed |
| EP-2411009-B1 | Therapeutic uses of quinazolinedione derivatives | SANOFI SA (FR) | 2013-03-20 | — | — | EP | disclosed |