Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CTSD | P07339 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL583112 | 0.82 | APEX1 (0.53) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL582525 | 0.82 | CTSV (0.50) | NPC1ALDH1A1CTSVCTSLBRD4 | |
| SCHEMBL581712 | 0.82 | HDAC3 (0.52) | ALDH1A1SMN1; SMN2MAPK1LMNAAPEX1 | |
| SCHEMBL2681682 | 0.79 | PDE4B (0.49) | SMN1; SMN2MAPK1CTSVCTSLBRD4 | |
| SCHEMBL2683839 | 0.78 | APEX1 (0.46) | PKMALDH1A1SMN1; SMN2MAPK1LMNA | |
| SCHEMBL2683893 | 0.78 | SMN1; SMN2 (0.48) | PKMALDH1A1SMN1; SMN2MAPK1LMNA | |
| SCHEMBL2684459 | 0.77 | NPC1 (0.52) | NPC1PKMRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2681785 | 0.75 | NPSR1 (0.48) | PKMALDH1A1SMN1; SMN2MAPK1HTT | |
| SCHEMBL6942692 | 0.75 | LMNA (0.49) | ALDH1A1SMN1; SMN2LMNAHPGDAPEX1 | |
| SCHEMBL6942695 | 0.75 | LMNA (0.49) | ALDH1A1SMN1; SMN2LMNAHPGDAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722659-B2 | Quinazolinedione derivatives, preparation thereof and various therapeutic uses thereof | SANOFI (FR) | 2014-05-13 | — | — | US | disclosed |
| US-8722659-B2 | Quinazolinedione derivatives, preparation thereof and various therapeutic uses thereof | SANOFI (FR) | 2014-05-13 | — | — | US | disclosed |
| US-20120115846-A1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND VARIOUS THERAPEUTIC USES THEREOF. | SANOFI (FR) | 2012-05-10 | — | — | US | disclosed |
| US-20120115846-A1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND VARIOUS THERAPEUTIC USES THEREOF. | SANOFI (FR) | 2012-05-10 | — | — | US | disclosed |
| WO-2010116088-A2 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND VARIOUS THERAPEUTIC USES THEREOF | SANOFI-AVENTIS (FR) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115846-A1 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND VARIOUS THERAPEUTIC USES THEREOF. | CYP27B1, NDUFB3, MT-ND5 | NPC1 2153/4885PKM 361/4885RAB9A 2427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.