Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.67 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | ARG2 | P78540 | 4/20 | 0.43 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1168516 | 0.93 | GSR (0.53) | GSRFOLH1RNPEPSLC6A5MMP2 | |
| SCHEMBL28786641 | 0.93 | GSR (0.53) | GSRFOLH1RNPEPSLC6A5MMP2 | |
| SCHEMBL1168511 | 0.93 | GSR (0.53) | GSRFOLH1RNPEPSLC6A5MMP2 | |
| SCHEMBL10430391 | 0.88 | FOLH1 (0.46) | GSRFOLH1RNPEPSLC6A5MMP2 | |
| SCHEMBL27529124 | 0.88 | FOLH1 (0.46) | GSRFOLH1RNPEPSLC6A5MMP2 | |
| SCHEMBL6616072 | 0.88 | FOLH1 (0.46) | GSRFOLH1RNPEPSLC6A5MMP2 | |
| Acrylamide SCHEMBL28112667 | 0.84 | FOLH1 (0.45) | GSRFOLH1RNPEPSLC6A5MMP2 | |
| Lysine SCHEMBL27830975 | 0.84 | GSR (0.95) | GSRARG2ARG1RNPEPNOS3 | |
| Lysine SCHEMBL27830974 | 0.84 | GSR (0.95) | GSRARG2ARG1RNPEPNOS3 | |
| Lysine SCHEMBL1130394 | 0.83 | GSR (0.71) | GSRFOLH1ARG2ARG1RNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3111953-A1 | WHOLE-INACTIVATED INFLUENZA VIRUS AS AN ADJUVANT FOR PEPTIDE ANTIGENS | De Staat der Nederlanden, vert. door de minister Van VWS, Ministerie van Volksgezondheid, Welzijn en Sport (NL) | 2017-01-04 | — | — | EP | disclosed |
| US-9522962-B2 | Peptides, conjugates and method for increasing immunogenicity of a vaccine | ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC (NL) | 2016-12-20 | — | — | US | disclosed |
| EP-2547364-B1 | Peptides, conjugates and method for increasing immunogenicity of a vaccine | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2016-12-14 | — | — | EP | disclosed |
| US-20130071428-A1 | PEPTIDES, CONJUGATES AND METHOD FOR INCREASING IMMUNOGENICITY OF A VACCINE | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2013-03-21 | — | — | US | disclosed |