Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.60 |
| ▸ | TSHR | P16473 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20120017 | 0.85 | SMN1; SMN2 (0.65) | SMN1; SMN2TSHRKMT2AMEN1HIF1A | |
| SCHEMBL14780386 | 0.85 | CCNB2 (0.56) | SMN1; SMN2TSHRKMT2AMEN1HIF1A | |
| SCHEMBL14779455 | 0.82 | SMN1; SMN2 (0.64) | SMN1; SMN2TSHRKMT2AMEN1HIF1A | |
| SCHEMBL14780042 | 0.82 | SMN1; SMN2 (0.64) | SMN1; SMN2TSHRKMT2AMEN1HIF1A | |
| SCHEMBL14779322 | 0.82 | SMN1; SMN2 (0.64) | SMN1; SMN2TSHRKMT2AMEN1HIF1A | |
| SCHEMBL14779860 | 0.82 | SMN1; SMN2 (0.64) | SMN1; SMN2TSHRKMT2AMEN1HIF1A | |
| SCHEMBL14778189 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2TSHRKMT2AMEN1HIF1A | |
| SCHEMBL14778104 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2TSHRKMT2AMEN1HIF1A | |
| SCHEMBL14778707 | 0.81 | CSF1R (0.69) | SMN1; SMN2TSHRKMT2AMEN1CYP1A2 | |
| SCHEMBL14778028 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2TSHRKMT2AMEN1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130072506-A1 | 6,8-DISUBSTITUTED PURINE COMPOSITIONS | ZAHAJSKA LENKA (CZ) | 2013-03-21 | — | — | US | claimed |
| EP-2755977-A1 | 6, 8- DISUBSTITUTED PURINE COMPOSITIONS AND THEIR PHARMACEUTICAL AND COSMETIC USE | Univerzita Palackého v Olomouci (CZ) | 2014-07-23 | — | — | EP | disclosed |
| WO-2013037333-A1 | 6, 8- DISUBSTITUTED PURINE COMPOSITIONS AND THEIR PHARMACEUTICAL AND COSMETIC USE | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2013-03-21 | — | — | WO | disclosed |
| US-20130072506-A1 | 6,8-DISUBSTITUTED PURINE COMPOSITIONS | ZAHAJSKA LENKA (CZ) | 2013-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072506-A1 | 6,8-DISUBSTITUTED PURINE COMPOSITIONS | UNG, PNP, UMPS | SMN1; SMN2 3262/4885TSHR 3236/4885KMT2A 2480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.