UMPS

Uridine 5'-monophosphate synthase

1,718 patent compounds predicted against UMPS, 1,084 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4635574	0.42	6/20
SCHEMBL16871796	0.57	5/20
SCHEMBL16871797	0.57	5/20
SCHEMBL10775311	0.50	5/20
SCHEMBL11406428	0.50	5/20
SCHEMBL11406434	0.50	5/20
SCHEMBL11755358	0.50	5/20
SCHEMBL11758791	0.50	5/20
SCHEMBL11178912	0.49	5/20
SCHEMBL11755974	0.49	5/20
SCHEMBL11760447	0.49	5/20
SCHEMBL1364683	0.48	5/20
SCHEMBL7269691	0.48	5/20
SCHEMBL3469594	0.47	5/20
SCHEMBL16710624	0.44	5/20
SCHEMBL16710628	0.44	5/20
SCHEMBL50310	0.42	5/20
SCHEMBL2028658	0.42	5/20
SCHEMBL13449624	0.42	5/20
SCHEMBL13466303	0.42	5/20

Germline variants in UMPS on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full UMPS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to UMPS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pharmacokinetics and Pharmacogenetics-based Adaptive Dosing of 5-fu (5-Fluorouracile) in Head & Neck Cancer Patient Undergoing Docetaxel, Cisplatin, 5-Fluorouracile (=TPF) Therapy	PHASE4	COMPLETED
Acelarin First Line Randomised Pancreatic Study	PHASE2/PHASE3	SUSPENDED
How Precision Diets, Through Gut Bacteria, Affect Anemia in Nepalese Adolescent	PHASE3	NOT_YET_RECRUITING
Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis	PHASE3	COMPLETED
Phase II Study of Ribose, Uridine, and Thymidine for a Complex Syndrome Involving Excessive 5'-Nucleotidase Activity	PHASE2	COMPLETED
A Phase II Study of TX Regimen as First-line Treatment for Asian Elderly Patients With Advanced Adenocarcinoma of Lung	PHASE2	COMPLETED
Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and Zidovudine	PHASE2	COMPLETED
A Trial of Gemcitabine, Infusional 5-Fluorouracil and Cisplatin for Advanced Pancreatic and Biliary Cancers	PHASE2	COMPLETED
Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma	PHASE2	UNKNOWN
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer	PHASE2	COMPLETED
A Phase 1/2 Study of STP938 (Dencatistat) for Adult Subjects With Relapsed/Refractory B-Cell and T-Cell Lymphomas	PHASE1/PHASE2	RECRUITING
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer	PHASE2	UNKNOWN
University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial	PHASE1/PHASE2	COMPLETED
Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer	PHASE2	ACTIVE_NOT_RECRUITING
Study of Relationship Between UGT1A1 Gene Polymorphism and Toxicity and Efficacy of Irinotecan in Small Cell Lung Cancer	PHASE2	UNKNOWN
Docetaxel Versus Docetaxel Plus Cisplatin Versus Docetaxel Plus S-1 as Second-line Chemotherapy in Metastatic Gastric Cancer	PHASE2	UNKNOWN
Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI + BevacizumabTreated Metastatic Colorectal Cancer	PHASE2	COMPLETED
Modelle 001, TS-inhibition in Colorectal Liver Metastases Comparing Arfolitixorin and Calciumfolinate	PHASE1/PHASE2	UNKNOWN
Combination Chemotherapy in Treating Patients Who Have Advanced Solid Tumors	PHASE1	COMPLETED
5-Fluoro-2'-Deoxcyctidine and Tetrahydrouridine to Treat Patients With Advanced Cancer	PHASE1	COMPLETED
Nab-paclitaxel (Abraxane), Gemcitabine, and Capecitabine (Xeloda) for Pancreatic Adenocarcinoma	PHASE1	COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Pharmacokinetic Interaction Study of Efavirenz and American Ginseng in Healthy Volunteers	PHASE1	COMPLETED
NUDT15/TPMT Multi-gene Guided 6-MP Dosing in Childhood ALL Maintenance Therapy	nan	NOT_YET_RECRUITING
Chronic Liver Disease in Urea Cycle Disorders	nan	COMPLETED
Predicting Response to Capecitabine in Women With Metastatic Breast Cancer	nan	COMPLETED
Functional Pharmacogenomics of Childhood Acute Lymphoblastic Leukemia in Taiwan	nan	UNKNOWN
A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders	nan	RECRUITING
Tumor Response to Pemetrexed Disodium in Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Enrolled in Clinical Trial MCCRC-RC0524	nan	COMPLETED
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a UMPS binder may also engage these)

Protein	Name	Similarity
Q5R514	—	1.000	Q5R514 →
P13439	—	0.997	P13439 →
P31754	—	0.989	P31754 →
A7M6E8	—	0.968	A7M6E8 →
Q80SY6	—	0.964	Q80SY6 →
B4G0F3	—	0.964	B4G0F3 →
Q9FUM8	—	0.964	Q9FUM8 →
A7M6E7	—	0.964	A7M6E7 →
Q8VBT2	—	0.963	Q8VBT2 →
Q9FUM9	—	0.961	Q9FUM9 →
Q6DHV7	—	0.961	Q6DHV7 →
Q68FT5	—	0.961	Q68FT5 →
Q0VC13	—	0.961	Q0VC13 →
O95671	—	0.960	O95671 →
Q5RF32	—	0.960	Q5RF32 →
Q8BGT5	—	0.960	Q8BGT5 →
BHMT2	S-methylmethionine--homocysteine S-methyltransferase BHMT2	0.960	landscape →
Q8R4N0	—	0.959	Q8R4N0 →
Q5R824	—	0.959	Q5R824 →
Q4V9J0	—	0.959	Q4V9J0 →
Q96NN9	—	0.959	Q96NN9 →
Q5R4R2	—	0.959	Q5R4R2 →
Q6NYP8	—	0.958	Q6NYP8 →
Q6GM82	—	0.958	Q6GM82 →
A5PLK2	—	0.958	A5PLK2 →
Q42942	—	0.958	Q42942 →
P17256	—	0.957	P17256 →
C6JS30	—	0.957	C6JS30 →
Q8SQ26	—	0.957	Q8SQ26 →
Q9Y2S2	—	0.957	Q9Y2S2 →