Sugi Predict

Sugi Predict / Targets / UMPS

UMPS

Uridine 5'-monophosphate synthase · P11172 · UMPS on Sugi Atlas →

1,718 patent compounds predicted against UMPS, 1,084 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL4635574 SCHEMBL4635574 0.42 6/20
SCHEMBL16871796 SCHEMBL16871796 0.57 5/20
SCHEMBL16871797 SCHEMBL16871797 0.57 5/20
SCHEMBL10775311 SCHEMBL10775311 0.50 5/20
SCHEMBL11406428 SCHEMBL11406428 0.50 5/20
SCHEMBL11406434 SCHEMBL11406434 0.50 5/20
SCHEMBL11755358 SCHEMBL11755358 0.50 5/20
SCHEMBL11758791 SCHEMBL11758791 0.50 5/20
SCHEMBL11178912 SCHEMBL11178912 0.49 5/20
SCHEMBL11755974 SCHEMBL11755974 0.49 5/20
SCHEMBL11760447 SCHEMBL11760447 0.49 5/20
SCHEMBL1364683 SCHEMBL1364683 0.48 5/20
SCHEMBL7269691 SCHEMBL7269691 0.48 5/20
SCHEMBL3469594 SCHEMBL3469594 0.47 5/20
SCHEMBL16710624 SCHEMBL16710624 0.44 5/20
SCHEMBL16710628 SCHEMBL16710628 0.44 5/20
SCHEMBL50310 SCHEMBL50310 0.42 5/20
SCHEMBL2028658 SCHEMBL2028658 0.42 5/20
SCHEMBL13449624 SCHEMBL13449624 0.42 5/20
SCHEMBL13466303 SCHEMBL13466303 0.42 5/20

Clinical trials — most relevant to UMPS by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pharmacokinetics and Pharmacogenetics-based Adaptive Dosing of 5-fu (5-Fluorouracile) in Head & Neck Cancer Patient Undergoing Docetaxel, Cisplatin, 5-Fluorouracile (=TPF) Therapy PHASE4COMPLETED
Acelarin First Line Randomised Pancreatic Study PHASE2/PHASE3SUSPENDED
How Precision Diets, Through Gut Bacteria, Affect Anemia in Nepalese Adolescent PHASE3NOT_YET_RECRUITING
Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis PHASE3COMPLETED
Phase II Study of Ribose, Uridine, and Thymidine for a Complex Syndrome Involving Excessive 5'-Nucleotidase Activity PHASE2COMPLETED
A Phase II Study of TX Regimen as First-line Treatment for Asian Elderly Patients With Advanced Adenocarcinoma of Lung PHASE2COMPLETED
Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and Zidovudine PHASE2COMPLETED
A Trial of Gemcitabine, Infusional 5-Fluorouracil and Cisplatin for Advanced Pancreatic and Biliary Cancers PHASE2COMPLETED
Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma PHASE2UNKNOWN
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer PHASE2COMPLETED
A Phase 1/2 Study of STP938 (Dencatistat) for Adult Subjects With Relapsed/Refractory B-Cell and T-Cell Lymphomas PHASE1/PHASE2RECRUITING
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer PHASE2UNKNOWN
University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial PHASE1/PHASE2COMPLETED
Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer PHASE2ACTIVE_NOT_RECRUITING
Study of Relationship Between UGT1A1 Gene Polymorphism and Toxicity and Efficacy of Irinotecan in Small Cell Lung Cancer PHASE2UNKNOWN
Docetaxel Versus Docetaxel Plus Cisplatin Versus Docetaxel Plus S-1 as Second-line Chemotherapy in Metastatic Gastric Cancer PHASE2UNKNOWN
Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI + BevacizumabTreated Metastatic Colorectal Cancer PHASE2COMPLETED
Modelle 001, TS-inhibition in Colorectal Liver Metastases Comparing Arfolitixorin and Calciumfolinate PHASE1/PHASE2UNKNOWN
Combination Chemotherapy in Treating Patients Who Have Advanced Solid Tumors PHASE1COMPLETED
5-Fluoro-2'-Deoxcyctidine and Tetrahydrouridine to Treat Patients With Advanced Cancer PHASE1COMPLETED
Nab-paclitaxel (Abraxane), Gemcitabine, and Capecitabine (Xeloda) for Pancreatic Adenocarcinoma PHASE1COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
Pharmacokinetic Interaction Study of Efavirenz and American Ginseng in Healthy Volunteers PHASE1COMPLETED
NUDT15/TPMT Multi-gene Guided 6-MP Dosing in Childhood ALL Maintenance Therapy nanNOT_YET_RECRUITING
Chronic Liver Disease in Urea Cycle Disorders nanCOMPLETED
Predicting Response to Capecitabine in Women With Metastatic Breast Cancer nanCOMPLETED
Functional Pharmacogenomics of Childhood Acute Lymphoblastic Leukemia in Taiwan nanUNKNOWN
A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders nanRECRUITING
Tumor Response to Pemetrexed Disodium in Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Enrolled in Clinical Trial MCCRC-RC0524 nanCOMPLETED
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a UMPS binder may also engage these)

ProteinNameSimilarity
Q5R514 — 1.000 Q5R514 →
P13439 — 0.997 P13439 →
P31754 — 0.989 P31754 →
A7M6E8 — 0.968 A7M6E8 →
Q80SY6 — 0.964 Q80SY6 →
B4G0F3 — 0.964 B4G0F3 →
Q9FUM8 — 0.964 Q9FUM8 →
A7M6E7 — 0.964 A7M6E7 →
Q8VBT2 — 0.963 Q8VBT2 →
Q9FUM9 — 0.961 Q9FUM9 →
Q6DHV7 — 0.961 Q6DHV7 →
Q68FT5 — 0.961 Q68FT5 →
Q0VC13 — 0.961 Q0VC13 →
O95671 — 0.960 O95671 →
Q5RF32 — 0.960 Q5RF32 →
BHMT2 S-methylmethionine--homocysteine S-methyltransferase BHMT2 0.960 landscape →
Q8BGT5 — 0.960 Q8BGT5 →
Q8R4N0 — 0.959 Q8R4N0 →
Q5R824 — 0.959 Q5R824 →
Q4V9J0 — 0.959 Q4V9J0 →
Q96NN9 — 0.959 Q96NN9 →
Q5R4R2 — 0.959 Q5R4R2 →
Q6NYP8 — 0.958 Q6NYP8 →
Q6GM82 — 0.958 Q6GM82 →
A5PLK2 — 0.958 A5PLK2 →
Q42942 — 0.958 Q42942 →
P17256 — 0.957 P17256 →
C6JS30 — 0.957 C6JS30 →
Q8SQ26 — 0.957 Q8SQ26 →
Q9Y2S2 — 0.957 Q9Y2S2 →