Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.40 |
| ▸ | STS | P08842 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646327 | 0.89 | PDPK1 (0.44) | PTPN2PTPN1PTPN6NPC1RAB9A | |
| SCHEMBL13545035 | 0.82 | TBK1 (0.41) | JAK1ABL1 | |
| SCHEMBL13374040 | 0.80 | PDPK1 (0.47) | ABL1 | |
| SCHEMBL8305843 | 0.79 | PDPK1 (0.46) | JAK1ABL1 | |
| SCHEMBL13375123 | 0.78 | PDPK1 (0.46) | NPC1RAB9A | |
| SCHEMBL10240120 | 0.77 | PDPK1 (0.49) | JAK1ABL1 | |
| SCHEMBL1646953 | 0.76 | TBK1 (0.42) | — | |
| SCHEMBL12305619 | 0.76 | PDPK1 (0.49) | JAK1ABL1 | |
| SCHEMBL13374042 | 0.76 | PDPK1 (0.48) | NPC1RAB9A | |
| SCHEMBL13373906 | 0.76 | ABL1 (0.49) | JAK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399442-B2 | Pharmaceutical compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2013-03-19 | — | — | US | disclosed |
| US-8399442-B2 | Pharmaceutical compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2013-03-19 | — | — | US | disclosed |