Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302949 | 1.00 | KDM4E (0.45) | KDM4EPARP1DHODHPDPK1FLT3 | |
| SCHEMBL1645725 | 1.00 | KDM4E (0.45) | KDM4EPARP1DHODHPDPK1FLT3 | |
| SCHEMBL13373935 | 0.88 | TSHR (0.49) | KDM4EPARP1DHODHPDPK1JAK2 | |
| SCHEMBL12303905 | 0.84 | KDM4E (0.55) | KDM4ELMNAPOLBTSHRALDH1A1 | |
| SCHEMBL1646056 | 0.84 | FLT3 (0.35) | FLT3LMNAMAPT | |
| SCHEMBL13373895 | 0.83 | PDPK1 (0.45) | KDM4EPDPK1JAK2TYK2LMNA | |
| SCHEMBL546166 | 0.83 | ALDH1A1 (0.41) | KDM4ELMNAPOLBTSHRALDH1A1 | |
| SCHEMBL12582697 | 0.83 | KDM4E (0.41) | KDM4EDHODHULK1AAK1 | |
| SCHEMBL1644923 | 0.83 | KDM4E (0.41) | KDM4EDHODHULK1AAK1 | |
| SCHEMBL13373905 | 0.82 | PDPK1 (0.47) | KDM4EPDPK1FLT3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399442-B2 | Pharmaceutical compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2013-03-19 | — | — | US | disclosed |
| US-8399442-B2 | Pharmaceutical compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2013-03-19 | — | — | US | disclosed |