Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049332 | 0.86 | LMNA (0.65) | LMNAMAPK1MAPTALDH1A1KDM4E | |
| SCHEMBL20839925 | 0.86 | LMNA (0.65) | LMNAMAPK1MAPTALDH1A1KDM4E | |
| SCHEMBL1269967 | 0.85 | LMNA (0.63) | LMNAMAPK1MAPTALDH1A1KDM4E | |
| SCHEMBL13806635 | 0.81 | MCL1 (0.58) | LMNAMAPK1MAPTALDH1A1KDM4E | |
| SCHEMBL31305767 | 0.80 | LMNA (0.69) | LMNAMAPK1MAPTALDH1A1KDM4E | |
| SCHEMBL31305775 | 0.80 | LMNA (0.69) | LMNAMAPK1MAPTALDH1A1KDM4E | |
| SCHEMBL4650805 | 0.79 | LMNA (0.56) | LMNAMAPK1MAPTALDH1A1KDM4E | |
| SCHEMBL9495325 | 0.78 | LMNA (1.00) | LMNAMAPK1MAPTALDH1A1KDM4E | |
| SCHEMBL1031488 | 0.78 | LMNA (0.71) | LMNAMAPK1MAPTALDH1A1KDM4E | |
| SCHEMBL4651653 | 0.78 | MAPK1 (0.71) | LMNAMAPK1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399454-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-19 | — | — | US | disclosed |