Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14786307 | 0.93 | GRM7 (0.35) | GRM7ALDH1A1MAPTHPGD | |
| SCHEMBL14786310 | 0.93 | GRM7 (0.35) | GRM7ALDH1A1MAPTHPGD | |
| SCHEMBL326219 | 0.82 | CNR2 (0.33) | ALDH1A1S1PR3CNR2P2RX3P2RX2 | |
| SCHEMBL12611337 | 0.81 | GRM7 (0.32) | GRM7ALDH1A1S1PR3CNR2 | |
| SCHEMBL536516 | 0.81 | GRM7 (0.32) | GRM7ALDH1A1S1PR3CNR2 | |
| SCHEMBL12497104 | 0.81 | GRM7 (0.32) | GRM7ALDH1A1S1PR3CNR2 | |
| SCHEMBL14785414 | 0.79 | CYP11B2 (0.40) | BACE1 | |
| SCHEMBL14790845 | 0.79 | GRM7 (0.35) | GRM7ALDH1A1MAPTHPGDCNR2 | |
| SCHEMBL17105467 | 0.78 | GRM7 (0.33) | GRM7P2RX3P2RX2 | |
| SCHEMBL16939926 | 0.77 | S1PR3 (0.33) | GRM7S1PR3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9078444-B2 | Isothiazoline derivatives as insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2015-07-14 | — | — | US | disclosed |
| US-20140378415-A1 | ISOTHIAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-12-25 | — | — | US | disclosed |
| EP-2755969-A1 | ISOTHIAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2014-07-23 | — | — | EP | disclosed |
| WO-2013037626-A1 | ISOTHIAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378415-A1 | ISOTHIAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS | CBR3, C1S, HRH2 | GRM7 4301/4885ALDH1A1 1473/4885S1PR3 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.