Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29590409 | 0.88 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14783762 | 0.88 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL29590480 | 0.85 | MAPT (0.60) | MAPTTP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14783338 | 0.85 | MAPT (0.60) | MAPTTP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL28233924 | 0.85 | MAPT (0.49) | MAPTTP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL29592435 | 0.83 | MAPT (0.49) | MAPTTP53SMN1; SMN2 | |
| SCHEMBL14783169 | 0.83 | MAPT (0.49) | MAPTTP53SMN1; SMN2 | |
| SCHEMBL14782951 | 0.81 | BRAF (0.59) | GAAKDM4E | |
| SCHEMBL27983909 | 0.80 | HCAR2 (0.48) | MAPTTP53SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL14783172 | 0.80 | MEN1 (0.47) | MAPTRAB9ANPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755657-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Neupharma, Inc. (US) | 2014-07-23 | — | — | EP | disclosed |
| WO-2013040515-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA, INC. (US) | 2013-03-21 | — | — | WO | disclosed |