Sugi Predict

Sugi Predict / Compounds / SCHEMBL147946

SCHEMBL147946

SCHEMBL147946

Fc1ccc(-c2ccc3cc[nH]c3c2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AHR P35869 4/20 0.70
▸ ESR1 P03372 2/20 0.50
▸ GPR84 Q9NQS5 1/20 0.50
▸ NPC1 O15118 1/20 0.48
▸ CMA1 P23946 1/20 0.48
▸ TYR P14679 1/20 0.48
▸ APP P05067 1/20 0.48
▸ FFAR4 Q5NUL3 1/20 0.47
▸ CHRNB4 P30926 1/20 0.47
▸ CHRNA3 P32297 1/20 0.47
▸ CHRNA7 P36544 1/20 0.47
▸ CHRNA10 Q9GZZ6 1/20 0.47
▸ CHRNA9 Q9UGM1 1/20 0.47
▸ GHSR Q92847 1/20 0.45
▸ BRD4 O60885 1/20 0.45
▸ PIP4K2A P48426 1/20 0.44
▸ PIP4K2B P78356 1/20 0.44
▸ CNR2 P34972 1/20 0.44
▸ ENPP2 Q13822 2/20 0.44
▸ MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL856313 0.84 AHR (0.70) AHRGPR84NPC1APPCHRNB4
SCHEMBL7087919 0.83 AHR (0.63) AHRGPR84NPC1CMA1TYR
SCHEMBL18805062 0.83 AHR (1.00) AHRESR1GPR84CMA1TYR
SCHEMBL29361924 0.83 AHR (1.00) AHRESR1GPR84CMA1TYR
SCHEMBL444450 0.83 AHR (1.00) AHRESR1GPR84CMA1TYR
SCHEMBL30253604 0.82 NPC1 (0.71) AHRNPC1CMA1TYRCHRNB4
SCHEMBL443799 0.82 NPC1 (0.71) AHRNPC1CMA1TYRCHRNB4
Methane SCHEMBL28804924 0.81 AHR (0.95) AHRESR1GPR84NPC1CMA1
SCHEMBL7085381 0.80 AHR (0.65) AHRESR1GPR84CMA1TYR
SCHEMBL1225643 0.80 TYR (0.70) AHRESR1NPC1CMA1TYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2391602-B1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2013-12-04 — — EP disclosed
US-8362065-B2 Carbazole carboxamide compounds useful as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-01-29 — — US disclosed
US-20120058996-A1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-03-08 — — US disclosed
US-8084620-B2 Carbazole carboxamide compounds useful as kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2011-12-27 — — US disclosed
EP-2391602-A1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS Bristol-Myers Squibb Company (US) 2011-12-07 — — EP disclosed
WO-2010080481-A1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2010-07-15 — — WO disclosed
US-20100160303-A1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2010-06-24 — — US disclosed
US-6867198-B2 Agents and methods for the treatment of proliferative diseases ELI LILLY AND COMPANY (US) 2005-03-15 — — US disclosed
US-6743785-B2 KINASE INHIBITORS; ANNULATED PYRROLE AND INDOLE RINGS; PYRROLO (3,2,1-HI)INDOLES; 3-(5,5-DIMETHYL-5,6-DIHYDRO-4H-PYRROLO (3,2,1-IJ)QUINOLIN-1-YL)-4-(1,2,3,4-TETRAHYDRO-(1,4) DIAZEPINO(6,7,1-HI)INDOL-7-YL)-PYRROLE-2,5-DIONE ELI LILLY AND COMPANY 2004-06-01 — — US disclosed
EP-1250334-B1 Medicaments useful for the treatment of proliferative diseases LILLY CO ELI (US) 2004-05-19 — — EP disclosed
US-5643922-A Indole cyclohexyl platelet activating factor antagonists ABBOTT LABORATORIES (US) 1997-07-01 — — US disclosed
WO-1996033196-A1 INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS ABBOTT LABORATORIES (US) 1996-10-24 — — WO disclosed
US-5567711-A Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists ABBOTT LABORATORIES (US) 1996-10-22 — — US disclosed
EP-0734386-A1 PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES Abbott Laboratories (US) 1996-10-02 — — EP disclosed
US-5486525-A ANTIINFLAMMATORY AGENTS ABBOTT LABORATORIES (US) 1996-01-23 — — US disclosed
US-5459152-A 3-(pyridin-3-yl)-7-(indol-3-yl)carbonyl-1H,3H-pyrrolo(1,2-c) thiazole derivatives; asthma ABBOTT LABORATORIES (US) 1995-10-17 — — US disclosed
WO-1995016687-A1 PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES ABBOTT LABORATORIES (US) 1995-06-22 — — WO disclosed
EP-0595924-A4 PLATELET ACTIVATING FACTOR ANTAGONISTS ABBOTT LAB (US) 1994-08-24 — — EP disclosed
EP-0595924-A1 PLATELET ACTIVATING FACTOR ANTAGONISTS ABBOTT LABORATORIES (US) 1994-05-11 — — EP disclosed
WO-1993001813-A1 PLATELET ACTIVATING FACTOR ANTAGONISTS ABBOTT LABORATORIES (US) 1993-02-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120058996-A1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, FLT3, JAK1 AHR 2309/4885ESR1 2264/4885GPR84 1255/4885
US-20100160303-A1 CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, FLT3, JAK1 AHR 2309/4885ESR1 2264/4885GPR84 1255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.