Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 10/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795325 | 0.89 | SYK (0.38) | MAP4K1SYKCYP2C9JAK3HSD17B2 | |
| SCHEMBL14795157 | 0.86 | HSD17B2 (0.40) | HSD17B2 | |
| SCHEMBL14795219 | 0.86 | SYK (0.40) | MAP4K1SYKCYP2C9JAK3CYP2D6 | |
| SCHEMBL14795092 | 0.85 | SYK (0.38) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL15755924 | 0.84 | HSD17B2 (0.50) | HSD17B2 | |
| SCHEMBL14795323 | 0.84 | SYK (0.37) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL14795122 | 0.84 | SYK (0.38) | SYKCYP2C9HSD17B2 | |
| SCHEMBL14795162 | 0.83 | PTGFR (0.39) | — | |
| SCHEMBL14795090 | 0.82 | SYK (0.41) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL14795227 | 0.82 | KDM4E (0.43) | SYKCYP2C9JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571880-A1 | PYRROLO [2, 3 - B]PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | disclosed |