Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 5/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795122 | 0.92 | SYK (0.38) | HSD17B2HSD17B1HDAC1AKT3 | |
| SCHEMBL15755924 | 0.91 | HSD17B2 (0.50) | HSD17B2HSD17B1HDAC1 | |
| SCHEMBL14795162 | 0.89 | PTGFR (0.39) | — | |
| SCHEMBL14795325 | 0.89 | SYK (0.38) | HSD17B2 | |
| SCHEMBL14795323 | 0.86 | SYK (0.37) | — | |
| SCHEMBL14795147 | 0.86 | MAP4K1 (0.46) | HSD17B2 | |
| SCHEMBL14795219 | 0.85 | SYK (0.40) | — | |
| SCHEMBL14795119 | 0.83 | HSD17B2 (0.45) | HSD17B2HSD17B1HDAC1AKT3 | |
| SCHEMBL15755864 | 0.83 | HSD17B2 (0.41) | HSD17B2HSD17B1HDAC1 | |
| SCHEMBL14795227 | 0.81 | KDM4E (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571880-A1 | PYRROLO [2, 3 - B]PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | disclosed |