Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 19/20 | 0.86 |
| ▸ | PDGFRB | P09619 | 17/20 | 0.86 |
| ▸ | KDR | P35968 | 17/20 | 0.86 |
| ▸ | FLT1 | P17948 | 4/20 | 0.70 |
| ▸ | LCK | P06239 | 2/20 | 0.70 |
| ▸ | FLT3 | P36888 | 2/20 | 0.70 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.70 |
| ▸ | PLK4 | O00444 | 1/20 | 0.70 |
| ▸ | STK25 | O00506 | 1/20 | 0.70 |
| ▸ | CIT | O14578 | 1/20 | 0.70 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.70 |
| ▸ | GAK | O14976 | 1/20 | 0.70 |
| ▸ | CHUK | O15111 | 1/20 | 0.70 |
| ▸ | MUSK | O15146 | 1/20 | 0.70 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.70 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.70 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.70 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.70 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795859 | 0.90 | FGFR1 (0.70) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL3379948 | 0.90 | FGFR1 (0.86) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL30567813 | 0.90 | FGFR1 (0.86) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL949705 | 0.90 | FGFR1 (0.86) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL12003201 | 0.89 | FGFR1 (0.85) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL14795876 | 0.87 | FGFR1 (0.68) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL3381227 | 0.85 | FGFR1 (0.85) | FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL3384622 | 0.85 | FGFR1 (0.70) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL3845013 | 0.84 | FGFR1 (0.88) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL946022 | 0.83 | FGFR1 (0.75) | FGFR1PDGFRBKDRFLT1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762475-A1 | Pharmaceutically acceptable salts of quinolinone compounds and their medical use | Novartis Vaccines and Diagnostics, Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| EP-2573079-A2 | Benzimidazole quinolinones and uses thereof | Novartis Vaccines and Diagnostics, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |