Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.76 |
| ▸ | AURKA | O14965 | 5/20 | 0.71 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.71 |
| ▸ | PRKCG | P05129 | 5/20 | 0.71 |
| ▸ | PRKCB | P05771 | 5/20 | 0.71 |
| ▸ | PRKCA | P17252 | 5/20 | 0.71 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.71 |
| ▸ | PRKCH | P24723 | 5/20 | 0.71 |
| ▸ | CDK2 | P24941 | 5/20 | 0.71 |
| ▸ | PRKCI | P41743 | 5/20 | 0.71 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.71 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.71 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.71 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.71 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.71 |
| ▸ | JAK1 | P23458 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378308 | 0.94 | CHEK1 (0.75) | CHEK1AURKAPRKD3PRKCGPRKCB | |
| SCHEMBL14796277 | 0.90 | CHEK1 (0.81) | CHEK1AURKAPRKD3PRKCGPRKCB | |
| SCHEMBL3379867 | 0.89 | CHEK1 (0.75) | CHEK1AURKAPRKD3PRKCGPRKCB | |
| SCHEMBL6388857 | 0.89 | CHEK1 (0.81) | CHEK1AURKAPRKD3PRKCGPRKCB | |
| SCHEMBL14796247 | 0.87 | CHEK1 (0.75) | CHEK1AURKAPRKD3PRKCGPRKCB | |
| SCHEMBL3378281 | 0.86 | CHEK1 (1.00) | CHEK1AURKAPRKD3PRKCGPRKCB | |
| SCHEMBL6390590 | 0.86 | CHEK1 (1.00) | CHEK1AURKAPRKD3PRKCGPRKCB | |
| SCHEMBL6389466 | 0.86 | CHEK1 (0.81) | CHEK1AURKAPRKD3PRKCGPRKCB | |
| SCHEMBL14795591 | 0.86 | CHEK1 (0.70) | CHEK1AURKAPRKD3PRKCGPRKCB | |
| SCHEMBL14796228 | 0.83 | CHEK1 (0.75) | CHEK1AURKAPRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762475-A1 | Pharmaceutically acceptable salts of quinolinone compounds and their medical use | Novartis Vaccines and Diagnostics, Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| EP-2573079-A2 | Benzimidazole quinolinones and uses thereof | Novartis Vaccines and Diagnostics, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |