Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | JAK1 | P23458 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 4/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.55 |
| ▸ | PRKCG | P05129 | 4/20 | 0.55 |
| ▸ | PRKCB | P05771 | 4/20 | 0.55 |
| ▸ | PRKCA | P17252 | 4/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.55 |
| ▸ | PRKCH | P24723 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 4/20 | 0.55 |
| ▸ | PRKCI | P41743 | 4/20 | 0.55 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.55 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378308 | 0.94 | CHEK1 (0.75) | CHEK1PDGFRBFGFR1KDRAURKA | |
| SCHEMBL14795486 | 0.89 | CHEK1 (0.76) | CHEK1JAK1AURKAPRKD3PRKCG | |
| SCHEMBL14796041 | 0.85 | CHEK1 (0.86) | CHEK1PDGFRBFGFR1KDRJAK1 | |
| SCHEMBL6390082 | 0.85 | CHEK1 (1.00) | CHEK1PDGFRBFGFR1KDRJAK1 | |
| SCHEMBL6393522 | 0.85 | CHEK1 (1.00) | CHEK1PDGFRBFGFR1KDRJAK1 | |
| SCHEMBL4690356 | 0.83 | PDGFRB (0.53) | CHEK1PDGFRBFGFR1KDRJAK1 | |
| SCHEMBL14796228 | 0.82 | CHEK1 (0.75) | CHEK1AURKAPRKD3PRKCGPRKCB | |
| SCHEMBL3379145 | 0.81 | CHEK1 (0.81) | CHEK1PDGFRBFGFR1KDRAURKA | |
| SCHEMBL3384480 | 0.81 | CHEK1 (0.81) | CHEK1PDGFRBFGFR1KDRAURKA | |
| SCHEMBL14796030 | 0.80 | CHEK1 (0.80) | CHEK1PDGFRBFGFR1KDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762475-A1 | Pharmaceutically acceptable salts of quinolinone compounds and their medical use | Novartis Vaccines and Diagnostics, Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| EP-2573079-A2 | Benzimidazole quinolinones and uses thereof | Novartis Vaccines and Diagnostics, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| EP-1497287-B1 | Quinoline derivatives in combination with 5-FU or CPT-11 for use in the treatment of cancer | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-11-24 | — | — | EP | disclosed |
| US-7825132-B2 | Inhibition of FGFR3 and treatment of multiple myeloma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-20100184754-A1 | QUINOLINONE DERIVATIVES | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2010-07-22 | — | — | US | disclosed |
| US-20090281100-A1 | Benzimidazole quinolinones and uses thereof | BARSANTI PAUL A | 2009-11-12 | — | — | US | disclosed |
| US-7598268-B2 | Quinolinone derivatives | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-7470709-B2 | Benzimidazole quinolinones and uses thereof | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| US-20080070906-A1 | QUINOLINONE DERIVATIVES | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2008-03-20 | — | — | US | disclosed |
| US-7335774-B2 | Quinolinone derivatives | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-20040097545-A1 | Quinolinone derivatives | NOVARTIS AG (CH) | 2004-05-20 | — | — | US | disclosed |
| US-20040092535-A1 | Benzimidazole quinolinones and uses thereof | CHIRON CORPORATION | 2004-05-13 | — | — | US | disclosed |
| US-20040006101-A1 | Quinolinone derivatives | CHIRON CORPORATION | 2004-01-08 | — | — | US | disclosed |
| WO-2003087095-A1 | QUINOLINONE DERIVATIVES | CHIRON CORPORATION (US) | 2003-10-23 | — | — | WO | disclosed |
| US-20030158224-A1 | Quinolinone derivatives | CHIRON CORPORATION | 2003-08-21 | — | — | US | disclosed |
| US-6605617-B2 | Treating a patient in need of an inhibitor of vascular endothelial growth factor receptor tyrosine kinase | CHIRON CORPORATION | 2003-08-12 | — | — | US | disclosed |
| EP-1317442-A1 | QUINOLINONE DERIVATIVES AS TYROSINE KINASE INHIBITORS | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| US-20030028018-A1 | Quinolinone derivatives | CHIRON COPORATION | 2003-02-06 | — | — | US | disclosed |
| US-20020107392-A1 | Quinolinone derivatives | NOVARTIS AG (CH) | 2002-08-08 | — | — | US | disclosed |
| WO-2002022598-A1 | QUINOLINONE DERIVATIVES AS TYROSINE KINASE INHIBITORS | CHIRON CORPORATION (US) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070906-A1 | QUINOLINONE DERIVATIVES | SLCO1B1, SLCO1B3, SLCO1A2 | CHEK1 3447/4885PDGFRB 4032/4885FGFR1 2959/4885 |
| US-20090281100-A1 | Benzimidazole quinolinones and uses thereof | GAA, ALPI, IL4I1 | CHEK1 2358/4885PDGFRB 3508/4885FGFR1 3018/4885 |
| US-20040097545-A1 | Quinolinone derivatives | SLCO1B1, SLCO1B3, SLCO1A2 | CHEK1 3389/4885PDGFRB 4039/4885FGFR1 2797/4885 |
| US-20030028018-A1 | Quinolinone derivatives | SLCO1B1, SLCO1B3, SLCO1A2 | CHEK1 3389/4885PDGFRB 4039/4885FGFR1 2797/4885 |
| US-20030158224-A1 | Quinolinone derivatives | SLCO1B1, SLCO1B3, SLCO1A2 | CHEK1 3389/4885PDGFRB 4039/4885FGFR1 2797/4885 |
| US-20020107392-A1 | Quinolinone derivatives | SLCO1B1, SLCO1B3, SLCO1A2 | CHEK1 3389/4885PDGFRB 4039/4885FGFR1 2797/4885 |
| US-20100184754-A1 | QUINOLINONE DERIVATIVES | SLCO1B1, SLCO1B3, SLCO1A2 | CHEK1 3447/4885PDGFRB 4032/4885FGFR1 2959/4885 |
| US-20040092535-A1 | Benzimidazole quinolinones and uses thereof | GAA, ALPI, IL4I1 | CHEK1 2295/4885PDGFRB 3542/4885FGFR1 2622/4885 |
| US-20040006101-A1 | Quinolinone derivatives | SLCO1B1, SLCO1B3, SLCO1A2 | CHEK1 3389/4885PDGFRB 4039/4885FGFR1 2797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.