Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 19/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 17/20 | 0.63 |
| ▸ | KDR | P35968 | 17/20 | 0.63 |
| ▸ | FLT1 | P17948 | 3/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384047 | 0.87 | FGFR1 (0.61) | FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL3741617 | 0.86 | FGFR1 (0.72) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL14795718 | 0.84 | FGFR1 (0.57) | FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL14795700 | 0.84 | FGFR1 (0.69) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL3380091 | 0.83 | FGFR1 (0.57) | FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL14795317 | 0.82 | FGFR1 (0.88) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL14795481 | 0.80 | FGFR1 (0.78) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL15910840 | 0.80 | FGFR1 (0.81) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL14795463 | 0.80 | FGFR1 (0.62) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL3382788 | 0.80 | FGFR1 (0.76) | FGFR1PDGFRBKDRFLT1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762475-A1 | Pharmaceutically acceptable salts of quinolinone compounds and their medical use | Novartis Vaccines and Diagnostics, Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| EP-2573079-A2 | Benzimidazole quinolinones and uses thereof | Novartis Vaccines and Diagnostics, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |