Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 11/20 | 0.43 |
| ▸ | GYS1 | P13807 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL14796800 | 0.91 | FFAR4 (0.52) | FFAR4GYS1KDM5AKDM4CKMT2A | |
| Bicarbonate SCHEMBL14796865 | 0.86 | GYS1 (0.47) | FFAR4GYS1KDM5AKDM4CKMT2A | |
| Bicarbonate SCHEMBL14796945 | 0.86 | FFAR4 (0.44) | FFAR4GYS1KDM5AKDM4CKMT2A | |
| SCHEMBL12071510 | 0.85 | FFAR4 (0.42) | FFAR4GYS1KDM5AKDM4CKMT2A | |
| SCHEMBL2432157 | 0.85 | FFAR4 (0.42) | FFAR4GYS1KDM5AKDM4CKMT2A | |
| SCHEMBL2431752 | 0.83 | FFAR4 (0.46) | FFAR4GYS1KDM5AKDM4CKMT2A | |
| SCHEMBL2434569 | 0.82 | FFAR4 (0.54) | FFAR4 | |
| SCHEMBL2435182 | 0.81 | FFAR4 (0.42) | FFAR4GYS1KDM5AKDM4CKMT2A | |
| SCHEMBL2432503 | 0.80 | FFAR4 (0.41) | FFAR4KDM5AKDM4CKMT2A | |
| SCHEMBL2433864 | 0.78 | FFAR4 (0.51) | FFAR4GYS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367793-B1 | GPR120 RECEPTOR AGONISTS AND USES THEREOF | METABOLEX INC (US) | 2013-03-27 | — | — | EP | claimed |