GYS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1756374	1.00	20/20
SCHEMBL1756376	1.00	20/20
SCHEMBL1756428	1.00	20/20
SCHEMBL1756438	1.00	20/20
SCHEMBL1760053	1.00	20/20
SCHEMBL1760111	1.00	20/20
SCHEMBL1760217	1.00	20/20
SCHEMBL1760272	1.00	20/20
SCHEMBL1760275	1.00	20/20
SCHEMBL1760291	1.00	20/20
SCHEMBL1760292	1.00	20/20
SCHEMBL1760309	1.00	20/20
SCHEMBL1760313	1.00	20/20
SCHEMBL1760337	1.00	20/20
SCHEMBL1760366	1.00	20/20
SCHEMBL1760375	1.00	20/20
SCHEMBL1760392	1.00	20/20
SCHEMBL1760394	1.00	20/20
SCHEMBL1760437	1.00	20/20
SCHEMBL1760493	1.00	20/20

Clinical trials — most relevant to GYS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Impact of Erythropoietin on Hematological Adaptations and Physical Performance	PHASE4	COMPLETED
The Effect of Triheptanoin on Fatty Acid Oxidation and Exercise Tolerance in Patients With Glycogenoses	PHASE2	COMPLETED
Triheptanoin in Mc Ardle	PHASE2	COMPLETED
The Effect of Triheptanoin in Adults With McArdle Disease (Glycogen Storage Disease Type V)	PHASE2	COMPLETED
Effect of Glycogen Replenishment on Time Trial Performance Following a Glycogen Lowering Exercise	nan	UNKNOWN
Galactose Mediated Glycogen Resynthesis	nan	COMPLETED
Cardiometabolic and Mental Health in the RGV	nan	WITHDRAWN
Lipid and Glycogen Metabolism in Patients With Impaired Glucose Tolerance and Calcium Sensing Receptor Mutations	nan	UNKNOWN
Molecular Response After Concurrent Exercise With Low Glycogen	nan	COMPLETED
Moderate Intensity Soleus Pushups Versus Sustained Soleus Pushups on Blood Glucose Level Among Young Population	nan	COMPLETED
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People	nan	COMPLETED
Carbohydrate Oxidation in Elite Wheelchair Racers During Marathon Simulation	nan	UNKNOWN
Carbohydrate Availability and microRNA Expression	nan	COMPLETED
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females	nan	COMPLETED
Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise	nan	COMPLETED
High Altitude Muscle Recovery	nan	COMPLETED
Insulin Sensitivity, Glucose - and Fat Metabolism in Patients With Psoriasis	nan	COMPLETED
Is Mid-morning Breakfast as Healthy as Early-morning Breakfast for Blood Sugar Control in Adolescent Girls?	nan	COMPLETED
The Effect of Blood Volume Changes on the Glucose Tolerance	nan	UNKNOWN
The Effect of Ketone Esters on Forearm Glucose Metabolism	nan	ACTIVE_NOT_RECRUITING
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.	nan	COMPLETED
Lactate Profile and Fat Oxidation During Exercise	nan	COMPLETED
Transcutaneous Electrical Diaphragmatic Stimulation in Critically Ill Elderly Patients	nan	UNKNOWN
Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting.	nan	NOT_YET_RECRUITING
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Impact of Physical Activity on Blood Glucose Stability and Energy Stores in Individuals With Type 1 Diabetes	nan	COMPLETED
Effect of Long-lasting Adaptation to Endurance and Speed-power Training on Plasma Free Amino Acids Concentration	nan	UNKNOWN
Energy Supplements to Improve Exercise Tolerance in Metabolic Myopathies	nan	COMPLETED
The GALAXY-1 Project	nan	UNKNOWN
Effect of Cryolipolysis on Insulin Resistance	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a GYS1 binder may also engage these)

Protein	Name	Similarity
Q9Z1E4	—	1.000	Q9Z1E4 →
Q5R9H0	—	1.000	Q5R9H0 →
P13834	—	1.000	P13834 →
Q8MJ26	—	1.000	Q8MJ26 →
O93869	—	1.000	O93869 →
J9VTK7	—	1.000	J9VTK7 →
GYS2	Glycogen [starch] synthase, liver	1.000	landscape →
A2RRU1	—	1.000	A2RRU1 →
P17625	—	1.000	P17625 →
P23337	—	1.000	P23337 →
Q9U2D9	—	1.000	Q9U2D9 →
Q8VCB3	—	0.995	Q8VCB3 →
P27472	—	0.995	P27472 →
A7MB78	—	0.995	A7MB78 →
Q9VFC8	—	0.994	Q9VFC8 →
B4NBB0	—	0.992	B4NBB0 →
P0AC87	—	0.992	P0AC87 →
Q2WF59	—	0.992	Q2WF59 →
P32811	—	0.991	P32811 →
Q9HBG4	—	0.991	Q9HBG4 →
P45180	—	0.991	P45180 →
Q84WW3	—	0.990	Q84WW3 →
F4IF36	—	0.990	F4IF36 →
Q6GPQ5	—	0.990	Q6GPQ5 →
O23461	—	0.990	O23461 →
Q10003	—	0.990	Q10003 →
Q7YZT6	—	0.990	Q7YZT6 →
Q9PKE6	—	0.990	Q9PKE6 →
Q5XHF8	—	0.990	Q5XHF8 →
Q8CFQ3	—	0.989	Q8CFQ3 →