SCHEMBL14797111

SCHEMBL14797111

Cc1cc(-c2nc3cnc(Oc4cccc(C(F)(F)F)c4F)nc3o2)cc(C)c1OCC(=O)O

nearest known ligand 0.65

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 3/20 0.65
CETP P11597 4/20 0.39
PTPN1 P18031 2/20 0.38
PPARD Q03181 7/20 0.36
PPARA Q07869 2/20 0.36
PPARG P37231 2/20 0.35
CEPT1 Q9Y6K0 1/20 0.34
FFAR1 O14842 1/20 0.34
CHEK2 O96017 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14797002 0.93 S1PR1 (0.65) S1PR1CETPPTPN1PPARDPPARA
SCHEMBL14797332 0.91 S1PR1 (0.69) S1PR1CETPPTPN1PPARDPPARA
SCHEMBL14797108 0.91 S1PR1 (0.70) S1PR1PTPN1PPARDPPARAPPARG
SCHEMBL14797076 0.88 S1PR1 (0.72) S1PR1CETPPTPN1PPARDPPARA
SCHEMBL2225216 0.87 S1PR1 (0.69) S1PR1CETPPTPN1PPARDPPARA
SCHEMBL14797136 0.85 S1PR1 (0.71) S1PR1CETPCEPT1
SCHEMBL14797000 0.85 S1PR1 (0.74) S1PR1CETPPTPN1CEPT1
SCHEMBL14797212 0.85 S1PR1 (0.66) S1PR1CETPPTPN1PPARDCEPT1
SCHEMBL14797329 0.84 S1PR1 (0.63) S1PR1CETPPTPN1PPARDPPARA
SCHEMBL14797097 0.84 S1PR1 (0.71) S1PR1CETPPTPN1PPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8846692-B2 Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring SANOFI (FR) 2014-09-30 US disclosed
US-20130079358-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING SANOFI (FR) 2013-03-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130079358-A1 CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING OXGR1, EDNRA, EDF1 S1PR1 129/4885CETP 3150/4885PTPN1 989/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.