Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | UQCRB | P14927 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | PARG | Q86W56 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7770388 | 0.82 | MEN1 (0.51) | ALDH1A1SMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL23345377 | 0.81 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL15840367 | 0.81 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL634085 | 0.81 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL2333640 | 0.79 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL2408403 | 0.79 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL3834643 | 0.79 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL12169369 | 0.79 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL4781214 | 0.79 | CA1 (0.61) | ALDH1A1SMN1; SMN2MAPTCYP3A4CYP2C9 | |
| SCHEMBL4006137 | 0.79 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799614-A1 | REMEDY FOR ISCHEMIC DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-10-08 | — | — | EP | claimed |
| US-7915295-B2 | Viricides; HIV antivirals effective against problematic drug escape mutants; N-[(1S,1aR,7bR)-4,7-difluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-1-yl]-N'-[5-(4-(sulfonamido)phenoxy)-2-pyridinyl]urea | MEDIVIR AB (SE) | 2011-03-29 | — | — | US | disclosed |
| EP-1701942-B1 | NON-NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS | MEDIVIR AB (SE) | 2009-12-09 | — | — | EP | disclosed |
| US-20080070951-A1 | Non-Nucleotide Reverse Transcriptase Inhibitors | MEDIVIR AB (SE) | 2008-03-20 | — | — | US | disclosed |
| EP-1701942-A1 | NON-NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS | MEDIVIR AB (SE) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005066131-A1 | NON-NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS | MEDIVIR AB (SE) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070951-A1 | Non-Nucleotide Reverse Transcriptase Inhibitors | RCOR1, RRM2, POLR1A | ALDH1A1 2075/4885SMN1; SMN2 3625/4885MAPT 4278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.