Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 10/20 | 0.49 |
| ▸ | PRKDC | P78527 | 5/20 | 0.47 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.45 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.45 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.45 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.45 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.45 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.45 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.45 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5446244 | 0.88 | MAOA (0.64) | MAOAPRKDCATP1A1ATP1B1ATP1A3 | |
| SCHEMBL14802155 | 0.85 | MAOA (0.49) | MAOAPRKDCATP1A1ATP1B1ATP1A3 | |
| SCHEMBL14447677 | 0.83 | PRKDC (0.48) | MAOAPRKDCATP1A1ATP1B1ATP1A3 | |
| SCHEMBL5446315 | 0.83 | MAOA (0.64) | MAOAPRKDCATP1A1ATP1B1ATP1A3 | |
| SCHEMBL5446303 | 0.81 | PRKDC (0.53) | MAOAPRKDCATP1A1ATP1B1ATP1A3 | |
| SCHEMBL14468610 | 0.78 | MAOA (0.43) | MAOAPRKDCATP1A1ATP1B1ATP1A3 | |
| SCHEMBL5448683 | 0.77 | PRKDC (0.49) | MAOAPRKDCATP1A1ATP1B1ATP1A3 | |
| SCHEMBL5454434 | 0.77 | MGAM (0.63) | MAOAPRKDCACE | |
| SCHEMBL5448690 | 0.73 | PRKDC (0.45) | MAOAPRKDCATP1A1ATP1B1ATP1A3 | |
| SCHEMBL14802151 | 0.72 | PRKDC (0.46) | PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404681-B2 | Xanthones, thioxanthones and acridinones as DNA-PK inhibitors | LUITPOLD PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |