Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14802160 | 0.87 | PRKDC (0.68) | PRKDCRAD52L3MBTL1MEN1KMT2A | |
| SCHEMBL14802157 | 0.77 | PRKDC (0.50) | PRKDCMEN1KMT2AMAPTKIF11 | |
| SCHEMBL14802158 | 0.71 | MAPT (0.68) | MAPTCYP2C19HTTGAAALDH1A1 | |
| SCHEMBL18949722 | 0.70 | AHR (0.57) | L3MBTL1MEN1KMT2AMAPTCYP2C19 | |
| SCHEMBL5440678 | 0.70 | PRKDC (0.61) | PRKDCL3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL14139228 | 0.70 | PRKDC (0.54) | PRKDCMEN1KMT2AMAPTCYP2C19 | |
| SCHEMBL5440733 | 0.68 | PRKDC (0.65) | PRKDCL3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL5444182 | 0.68 | PRKDC (1.00) | PRKDCL3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL10067357 | 0.67 | MEN1 (0.65) | MEN1KMT2AMAPTCYP2C19HTT | |
| SCHEMBL30480878 | 0.67 | PRKDC (0.44) | PRKDCMEN1KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404681-B2 | Xanthones, thioxanthones and acridinones as DNA-PK inhibitors | LUITPOLD PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |