Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 10/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | ECE1 | P42892 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5454434 | 0.85 | MGAM (0.63) | PRKDCACEECE1KDM4EALDH1A1 | |
| SCHEMBL14802159 | 0.77 | PRKDC (0.52) | PRKDCKDM4EALDH1A1GAANPC1 | |
| SCHEMBL6895175 | 0.75 | MAOA (0.57) | KDM4EALDH1A1MAOAMGAMGAA | |
| SCHEMBL14802143 | 0.75 | PRKDC (0.52) | PRKDCMAOAMGAMGAASI | |
| SCHEMBL29888461 | 0.74 | TSHR (0.56) | PRKDCACEECE1KDM4EALDH1A1 | |
| SCHEMBL9837650 | 0.73 | MGAM (0.72) | KDM4EALDH1A1MAOAMGAMGAA | |
| SCHEMBL1938064 | 0.72 | SLC16A3 (0.51) | PRKDCACEECE1KDM4EALDH1A1 | |
| SCHEMBL5440694 | 0.72 | PRKDC (0.55) | PRKDCACEKDM4EALDH1A1MAOA | |
| SCHEMBL1794501 | 0.71 | MAOA (0.63) | KDM4EALDH1A1MAOAMGAMGAA | |
| SCHEMBL18949722 | 0.71 | AHR (0.57) | KDM4EALDH1A1GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404681-B2 | Xanthones, thioxanthones and acridinones as DNA-PK inhibitors | LUITPOLD PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |