SCHEMBL14802201

SCHEMBL14802201

COc1cc(C)cc2c1OC1(C=C2)N(Cc2ccc(F)cc2)c2ccccc2C1(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 11/20 0.44
LMNA P02545 6/20 0.44
KMT2A Q03164 4/20 0.44
THRB P10828 4/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
GAA P10253 3/20 0.44
MEN1 O00255 3/20 0.44
RECQL P46063 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
PLIN1 O60240 1/20 0.44
PKM P14618 1/20 0.44
TSHR P16473 1/20 0.44
PLIN5 Q00G26 1/20 0.44
ABHD5 Q8WTS1 1/20 0.44
MAPK1 P28482 1/20 0.36
TP53 P04637 4/20 0.35
NPSR1 Q6W5P4 3/20 0.35
ALPG P10696 1/20 0.35
ALOX15 P16050 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14143154 0.90 MAPT (0.44) MAPTLMNAKMT2ATHRBSMN1; SMN2
SCHEMBL13300482 0.89 GAA (0.43) MAPTLMNAKMT2ATHRBSMN1; SMN2
SCHEMBL13419411 0.88 MAPT (0.42) MAPTLMNAKMT2ATHRBSMN1; SMN2
SCHEMBL14069364 0.88 MAPT (0.44) MAPTLMNAKMT2ATHRBSMN1; SMN2
SCHEMBL13486420 0.87 MAPT (0.42) MAPTLMNAKMT2ATHRBSMN1; SMN2
SCHEMBL8775699 0.87 MAPT (0.42) MAPTLMNAKMT2ATHRBSMN1; SMN2
SCHEMBL13491294 0.83 MAPT (0.43) MAPTLMNAKMT2ATHRBSMN1; SMN2
SCHEMBL12846405 0.83 GAA (0.45) MAPTLMNAKMT2ATHRBSMN1; SMN2
SCHEMBL12787057 0.82 GAA (0.39) MAPTLMNAKMT2ATHRBSMN1; SMN2
SCHEMBL12265911 0.82 MAPT (0.44) MAPTLMNAKMT2ATHRBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8403558-B2 TTI indicator with balanced photochemical processes BIZERBA GMBH & CO. KG (DE) 2013-03-26 US disclosed