SCHEMBL148048

SCHEMBL148048

Cc1cccc(C(F)(F)F)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 1/20 0.55
TSHR P16473 2/20 0.54
MAPK1 P28482 1/20 0.54
MEN1 O00255 1/20 0.53
HTT P42858 1/20 0.53
RAB9A P51151 1/20 0.53
KMT2A Q03164 1/20 0.53
ACHE P22303 2/20 0.52
RAPGEF4 Q8WZA2 1/20 0.52
KCNK3 O14649 1/20 0.51
KCNK9 Q9NPC2 1/20 0.51
CES2 O00748 1/20 0.48
MGLL Q99685 1/20 0.48
ALDH1A1 P00352 1/20 0.48
IDH2 P48735 1/20 0.47
KIF11 P52732 1/20 0.47
HTR2A P28223 1/20 0.47
HTR2C P28335 1/20 0.47
HTR2B P41595 1/20 0.47
FFAR1 O14842 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL27462091 0.98 NFE2L2 (0.53) NFE2L2TSHRMAPK1MEN1HTT
Ammonia Solution, Strong SCHEMBL1869257 0.98 NFE2L2 (0.53) NFE2L2TSHRMAPK1MEN1HTT
Methylamine SCHEMBL3364530 0.95 TSHR (0.56) NFE2L2TSHRMAPK1MEN1HTT
SCHEMBL2341190 0.91 HTT (0.51) NFE2L2TSHRMAPK1MEN1HTT
M-Xylene SCHEMBL21585133 0.91 TSHR (0.56) NFE2L2TSHRMAPK1MEN1HTT
Ethylamine SCHEMBL8079279 0.89 TAAR1 (0.52) NFE2L2TSHRMAPK1MEN1HTT
Acetone SCHEMBL27922108 0.89 MEN1 (0.58) NFE2L2MEN1HTTRAB9AKMT2A
SCHEMBL16551075 0.88 CDK1 (0.50) NFE2L2TSHRMAPK1MEN1HTT
SCHEMBL2662898 0.87 PTPN5 (0.62) NFE2L2TSHRMAPK1MEN1HTT
SCHEMBL25485520 0.86 HTT (0.48) NFE2L2TSHRMAPK1MEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4630 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120054584-A Z-type CdS@g-C3N4At benzyl and aliphatic sp3C-H activation and CO2Application of photocatalytic carboxylation 重庆工商大学 2025-05-30 CN claimed
EP-4399212-A1 SUBSTITUTED 2,3-DIHYDRO[1,3]THIAZOLO[4,5-B]PYRIDINES, SALTS THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES Bayer Aktiengesellschaft (DE) 2024-07-17 EP claimed
US-20240218022-A1 ANTI-VISTA MACROCYCLIC PEPTIDES AND COMPOSITIONS BRISTOL-MYERS SQUIBB COMPANY (US) 2024-07-04 US claimed
EP-3315579-B1 SURFACE TREATMENT AGENT INCLUDING PERFLUORO(POLY)ETHER GROUP-CONTAINING SILANE COMPOUND DAIKIN IND LTD (JP) 2024-05-01 EP claimed
US-20240136585-A1 ELECTROLYTES FOR LITHIUM-CONTAINING BATTERY CELLS APPLE INC. (US) 2024-04-25 US claimed
US-11881558-B2 Electrolytes for lithium-containing battery cells APPLE INC. (US) 2024-01-23 US claimed
EP-4273147-A1 SUBSTITUTED SPIROLACTAMS, SALTS THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES Bayer Aktiengesellschaft (DE) 2023-11-08 EP claimed
US-20230278958-A1 TRICYCLIC HETEROCYCLES MERCK PATENT GMBH (DE) 2023-09-07 US claimed
US-20230174538-A1 Tricyclic heterocycles MERCK PATENT GMBH (DE) 2023-06-08 US claimed
WO-2023078813-A1 HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS MERCK PATENT GMBH (DE) 2023-05-11 WO claimed
WO-2000041469-A2 β-PHENYLALANINE DERIVATIVES AS INTEGRIN ANTAGONISTS BAYER AKTIENGESELLSCHAFT (DE) 2000-07-20 WO claimed
EP-1015444-A1 NOVEL PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION, LTD. (KR) 2000-07-05 EP claimed
US-6060453-A Immunomodulatory, anti-inflammatory, and anti-proliferative compounds: 5,6-dideoxy, 5-amino derivatives of idose and 6-deoxy, 6-amino derivatives of glucose GREENWICH PHARMACEUTICALS INCORPORATED (US) 2000-05-09 US claimed
WO-1998043968-A1 NOVEL PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 1998-10-08 WO claimed
US-5104869-A Renin inhibitors AMERICAN CYANAMID COMPANY (US) 1992-04-14 US claimed
EP-0292816-B1 PROCESS FOR THE PREPARATION OF META-TRIFLUOROMETHYLPHENYLACETONITRILE Degussa Aktiengesellschaft (DE) 1991-07-10 EP claimed
EP-0427939-A2 Renin inhibitors AMERICAN CYANAMID COMPANY (US) 1991-05-22 EP claimed
US-4824987-A Method of preparing m-trifluoromethylphenyl acetonitrile DEGUSSA AKTIENGESELLSCHAFT (DE) 1989-04-25 US claimed
EP-0292816-A1 Process for the preparation of meta-trifluoromethylphenylacetonitrile Degussa Aktiengesellschaft (DE) 1988-11-30 EP claimed
US-4508663-A Process for preparing thiosulfenamide derivatives of N-phosphonomethylglycinonitriles MONSANTO COMPANY (US) 1985-04-02 US claimed