Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.67 |
| ▸ | FLT3 | P36888 | 2/20 | 0.67 |
| ▸ | KDR | P35968 | 6/20 | 0.65 |
| ▸ | MET | P08581 | 4/20 | 0.65 |
| ▸ | FLT1 | P17948 | 3/20 | 0.65 |
| ▸ | KIT | P10721 | 2/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | PGR | P06401 | 1/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | HCK | P08631 | 1/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30918289 | 0.83 | AXL (0.90) | AURKBFLT3KDRMETFLT1 | |
| SCHEMBL15872120 | 0.83 | AXL (0.90) | AURKBFLT3KDRMETFLT1 | |
| SCHEMBL23923068 | 0.83 | PDGFRA (0.69) | AURKBKDRMETKITAURKA | |
| SCHEMBL16083195 | 0.83 | AURKB (0.85) | AURKBFLT3KDRMETFLT1 | |
| SCHEMBL12025694 | 0.81 | AURKB (0.85) | AURKBFLT3KDRMETFLT1 | |
| SCHEMBL372142 | 0.81 | AURKB (1.00) | AURKBFLT3KDRMETFLT1 | |
| SCHEMBL371951 | 0.80 | AURKB (0.87) | AURKBFLT3KDRMETFLT1 | |
| SCHEMBL15509288 | 0.80 | AURKB (0.83) | AURKBFLT3KDRMETFLT1 | |
| SCHEMBL17433337 | 0.80 | AXL (0.84) | AURKBFLT3KDRMETFLT1 | |
| SCHEMBL23880322 | 0.80 | PDGFRA (0.60) | AURKBFLT3KDRMETFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758057-A1 | METHOD FOR TREATING OSTEOPOROSIS | Exelixis, Inc. (US) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013043840-A1 | METHOD FOR TREATING OSTEOPOROSIS | EXELIXIS, INC. (US) | 2013-03-28 | — | — | WO | disclosed |