Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 9/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 9/20 | 0.58 |
| ▸ | MET | P08581 | 3/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 2/20 | 0.57 |
| ▸ | TEK | Q02763 | 2/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.57 |
| ▸ | AXL | P30530 | 2/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794599 | 0.81 | FGFR2 (0.69) | PDGFRAPDGFRBAURKBKDRMET | |
| SCHEMBL23923068 | 0.81 | PDGFRA (0.69) | PDGFRAPDGFRBAURKBKDRMET | |
| SCHEMBL29973365 | 0.81 | PDGFRA (0.62) | PDGFRAPDGFRBAURKBFLT3KDR | |
| SCHEMBL28374301 | 0.81 | FLT3 (0.60) | PDGFRAPDGFRBAURKBFLT3KDR | |
| SCHEMBL15509288 | 0.80 | AURKB (0.83) | PDGFRAAURKBFLT3KDRMET | |
| SCHEMBL28378727 | 0.80 | PDGFRA (0.57) | PDGFRAPDGFRBAURKBFLT3KDR | |
| SCHEMBL14808762 | 0.80 | AURKB (0.67) | PDGFRAPDGFRBAURKBFLT3KDR | |
| SCHEMBL6228087 | 0.78 | PDGFRA (0.79) | PDGFRAAURKBFLT3KDRMET | |
| SCHEMBL7486400 | 0.78 | FGFR2 (0.84) | PDGFRAPDGFRBKDREGFRFGFR2 | |
| SCHEMBL7485158 | 0.77 | FGFR2 (0.71) | PDGFRAPDGFRBAURKBFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230391789-A1 | BICYCLIC COMPOUNDS AS KINASE MODULATORS, METHODS AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2023-12-07 | — | — | US | disclosed |
| US-11702425-B2 | Bicyclic compounds as kinase modulators, methods and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2023-07-18 | — | — | US | disclosed |
| US-20210309668-A1 | BICYCLIC COMPOUNDS AS KINASE MODULATORS, METHODS AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702425-B2 | Bicyclic compounds as kinase modulators, methods and uses thereof | HCCS, PRKAA1, PRKAA2 | PDGFRA 1331/4885PDGFRB 1041/4885AURKB 158/4885 |
| US-20230391789-A1 | BICYCLIC COMPOUNDS AS KINASE MODULATORS, METHODS AND USES THEREOF | HCCS, PRKAA1, PRKAA2 | PDGFRA 1331/4885PDGFRB 1041/4885AURKB 158/4885 |
| US-20210309668-A1 | BICYCLIC COMPOUNDS AS KINASE MODULATORS, METHODS AND USES THEREOF | HCCS, PRKAA1, PRKAA2 | PDGFRA 1331/4885PDGFRB 1041/4885AURKB 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.