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Sugi Predict / Compounds / SCHEMBL1480928

SCHEMBL1480928

SCHEMBL1480928

COC(=O)c1ccc(Cn2cc(-c3ccc(Cl)cc3Cl)nc2/C=C/c2ccc(-c3cccc(NS(=O)(=O)C(F)(F)F)c3)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ DRD2 P14416 2/20 0.41
▸ POLB P06746 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ PPARA Q07869 2/20 0.36
▸ PPARG P37231 1/20 0.36
▸ PLAU P00749 1/20 0.36
▸ NLRP3 Q96P20 1/20 0.34
▸ TBXA2R P21731 1/20 0.34
▸ ALPL P05186 1/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ HSP90AA1 P07900 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ TLR9 Q9NR96 1/20 0.33
▸ KDM1A O60341 1/20 0.33
▸ F2 P00734 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1480930 1.00 DRD2 (0.41) DRD2POLBMAPTPPARAPPARG
SCHEMBL1483842 0.92 PPARA (0.38) POLBPPARAPPARGMEN1KMT2A
SCHEMBL1483845 0.92 PPARA (0.38) POLBPPARAPPARGMEN1KMT2A
SCHEMBL1676579 0.92 DRD2 (0.40) DRD2POLBMAPTPLAUNLRP3
SCHEMBL1676577 0.92 DRD2 (0.40) DRD2POLBMAPTPLAUNLRP3
SCHEMBL1482034 0.92 DRD2 (0.43) DRD2POLBMAPTPLAUNLRP3
SCHEMBL1482037 0.92 DRD2 (0.43) DRD2POLBMAPTPLAUNLRP3
SCHEMBL1676136 0.88 DRD2 (0.39) DRD2POLBMAPTPPARAPPARG
SCHEMBL1481344 0.87 DRD2 (0.44) DRD2POLBMAPTPLAUNLRP3
SCHEMBL1481346 0.87 DRD2 (0.44) DRD2POLBMAPTPLAUNLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110092553-A1 Substituted Azole Derivatives, Compositions, and Methods of Use TRANSTECH PHARMA, INC. (US) 2011-04-21 — — US disclosed
US-20110092553-A1 Substituted Azole Derivatives, Compositions, and Methods of Use TRANSTECH PHARMA, INC. (US) 2011-04-21 — — US disclosed
US-20110077399-A1 Substituted Azole Derivatives as Therapeutic Agents TRANSTECH PHARMA, INC. (US) 2011-03-31 — — US disclosed
US-20110077399-A1 Substituted Azole Derivatives as Therapeutic Agents TRANSTECH PHARMA, INC. (US) 2011-03-31 — — US disclosed
US-20050187277-A1 Substituted azole derivatives, compositions, and methods of use TRANSTECH PHARMA, INC. 2005-08-25 — — US disclosed
US-20040192743-A1 Substituted azole derivatives as therapeutic agents TRANSTECH PHARMA, INC. 2004-09-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040192743-A1 Substituted azole derivatives as therapeutic agents PTPRS, PTPRO, PTPRJ DRD2 4864/4885POLB 4328/4885MAPT 3558/4885
US-20110092553-A1 Substituted Azole Derivatives, Compositions, and Methods of Use PTPRO, PTPN5, PTPRE DRD2 4873/4885POLB 4497/4885MAPT 3251/4885
US-20050187277-A1 Substituted azole derivatives, compositions, and methods of use PTPRO, PTPN5, PTPRE DRD2 4873/4885POLB 4497/4885MAPT 3251/4885
US-20110077399-A1 Substituted Azole Derivatives as Therapeutic Agents PTPRS, PTPRO, PTPRJ DRD2 4864/4885POLB 4328/4885MAPT 3558/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.