Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 8/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 8/20 | 0.44 |
| ▸ | ITGAL | P20701 | 8/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16008007 | 1.00 | ITGB2 (0.44) | ITGB2ICAM1ITGALHDAC3HDAC1 | |
| SCHEMBL14811001 | 0.97 | ITGB2 (0.42) | ITGB2ICAM1ITGALHDAC3HDAC1 | |
| SCHEMBL16007915 | 0.97 | ITGB2 (0.42) | ITGB2ICAM1ITGALHDAC3HDAC1 | |
| SCHEMBL16007167 | 0.95 | ITGB2 (0.43) | ITGB2ICAM1ITGALHDAC3HDAC1 | |
| SCHEMBL14811840 | 0.95 | ITGB2 (0.43) | ITGB2ICAM1ITGALHDAC3HDAC1 | |
| SCHEMBL14811735 | 0.89 | ITGB2 (0.40) | ITGB2ICAM1ITGALHDAC3HDAC1 | |
| SCHEMBL16008287 | 0.89 | ITGB2 (0.40) | ITGB2ICAM1ITGALHDAC3HDAC1 | |
| SCHEMBL14812189 | 0.89 | HDAC3 (0.41) | ITGB2ICAM1ITGALHDAC3HDAC1 | |
| SCHEMBL16007945 | 0.89 | HDAC3 (0.41) | ITGB2ICAM1ITGALHDAC3HDAC1 | |
| SCHEMBL14812139 | 0.89 | HDAC3 (0.41) | ITGB2ICAM1ITGALHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855431-B1 | FSH RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (NL) | 2016-07-06 | — | — | EP | claimed |
| US-9044463-B2 | FSH receptor antagonists | MERCK SHARP & DOHME B.V. (NL) | 2015-06-02 | — | — | US | claimed |
| EP-2855431-A1 | FSH RECEPTOR ANTAGONISTS | Merck Sharp & Dohme B.V. (NL) | 2015-04-08 | — | — | EP | claimed |
| US-20140256725-A1 | FSH RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME B.V. (NL) | 2014-09-11 | — | — | US | claimed |
| WO-2013041461-A1 | FSH RECEPTOR ANTAGONISTS | MSD OSS B.V. (NL) | 2013-03-28 | — | — | WO | claimed |
| EP-2855431-B1 | FSH RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (NL) | 2016-07-06 | — | — | EP | disclosed |
| US-9044463-B2 | FSH receptor antagonists | MERCK SHARP & DOHME B.V. (NL) | 2015-06-02 | — | — | US | disclosed |
| EP-2855431-A1 | FSH RECEPTOR ANTAGONISTS | Merck Sharp & Dohme B.V. (NL) | 2015-04-08 | — | — | EP | disclosed |
| US-20140256725-A1 | FSH RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME B.V. (NL) | 2014-09-11 | — | — | US | disclosed |
| WO-2013041461-A1 | FSH RECEPTOR ANTAGONISTS | MSD OSS B.V. (NL) | 2013-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256725-A1 | FSH RECEPTOR ANTAGONISTS | FSHR, GNRHR, LHCGR | ITGB2 1628/4885ICAM1 3740/4885ITGAL 1587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.