SCHEMBL14812554

SCHEMBL14812554

O=C(O)Cc1ccc(CNC(=O)c2ccccc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 7/20 0.70
HDAC1 Q13547 6/20 0.70
EPHX2 P34913 2/20 0.69
NR1H4 Q96RI1 2/20 0.69
HDAC2 Q92769 5/20 0.62
HDAC8 Q9BY41 4/20 0.62
ERCC1 P07992 1/20 0.61
ERCC4 Q92889 1/20 0.61
HDAC3 O15379 4/20 0.60
PPARG P37231 1/20 0.60
HDAC4 P56524 2/20 0.59
HDAC7 Q8WUI4 2/20 0.59
HDAC10 Q969S8 2/20 0.59
HDAC11 Q96DB2 2/20 0.59
HDAC9 Q9UKV0 2/20 0.59
HDAC5 Q9UQL6 2/20 0.59
HPGD P15428 1/20 0.58
TP53 P04637 1/20 0.57
LMNA P02545 1/20 0.57
RAB9A P51151 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL457082 0.87 HDAC6 (0.79) HDAC6HDAC1EPHX2NR1H4HDAC2
SCHEMBL29184442 0.85 HDAC6 (0.76) HDAC6HDAC1EPHX2NR1H4HDAC2
Hydrochloric Acid SCHEMBL3757721 0.85 HDAC6 (0.76) HDAC6HDAC1EPHX2NR1H4HDAC2
SCHEMBL14812179 0.85 HDAC6 (0.73) HDAC6HDAC1EPHX2NR1H4HDAC2
SCHEMBL2062871 0.84 HDAC1 (0.73) HDAC6HDAC1EPHX2NR1H4HDAC2
SCHEMBL2777733 0.84 HDAC6 (0.72) HDAC6HDAC1EPHX2NR1H4HDAC2
SCHEMBL10099575 0.84 NR1H4 (0.84) HDAC6HDAC1EPHX2NR1H4HDAC2
SCHEMBL14812439 0.83 HDAC1 (0.63) HDAC6HDAC1EPHX2NR1H4HDAC2
SCHEMBL11357235 0.83 ESRRG (0.68) HDAC6HDAC1HDAC2HDAC8HDAC3
SCHEMBL11900090 0.83 HDAC6 (0.85) HDAC6HDAC1EPHX2NR1H4HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013041407-A1 HYDROXAMIC ACIDS AS HDAC6 INHIBITORS CELLZOME AG (DE) 2013-03-28 WO disclosed
WO-2013041407-A1 HYDROXAMIC ACIDS AS HDAC6 INHIBITORS CELLZOME AG (DE) 2013-03-28 WO disclosed