Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 16/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 16/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 16/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 15/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16339086 | 1.00 | HDAC2 (0.56) | HDAC2HDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL16338950 | 0.98 | HDAC2 (0.55) | HDAC2HDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL16338949 | 0.85 | SPHK1 (0.53) | HDAC2HDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL11669294 | 0.85 | SPHK1 (0.66) | HDAC2HDAC3HDAC6HDAC1HDAC8 | |
| SCHEMBL13820164 | 0.84 | LTA4H (0.70) | HDAC2LTA4HSPHK1 | |
| SCHEMBL16338952 | 0.84 | HDAC1 (0.52) | HDAC2HDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL25384893 | 0.83 | LTA4H (0.57) | HDAC2LTA4HSPHK1 | |
| Hydrochloric Acid SCHEMBL14230868 | 0.83 | LTA4H (0.68) | HDAC2HDAC8LTA4HSPHK1 | |
| SCHEMBL9267426 | 0.81 | MEN1 (0.61) | HDAC2HDAC3HDAC11HDAC6HDAC1 | |
| SCHEMBL5264997 | 0.81 | MEN1 (0.61) | HDAC2HDAC3HDAC11HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758371-B1 | NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS | SIGMA TAU IND FARMACEUTI (IT) | 2016-06-15 | — | — | EP | claimed |
| US-8927533-B2 | Thio derivatives bearing lactams as potent HDAC inhibitors and their uses as medicaments | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2015-01-06 | — | — | US | claimed |
| EP-2758371-A1 | NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2014-07-30 | — | — | EP | claimed |
| WO-2013041480-A1 | NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2013-03-28 | — | — | WO | claimed |
| EP-2758371-B1 | NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS | SIGMA TAU IND FARMACEUTI (IT) | 2016-06-15 | — | — | EP | disclosed |
| EP-2758371-B1 | NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS | SIGMA TAU IND FARMACEUTI (IT) | 2016-06-15 | — | — | EP | disclosed |
| US-8927533-B2 | Thio derivatives bearing lactams as potent HDAC inhibitors and their uses as medicaments | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2015-01-06 | — | — | US | disclosed |
| EP-2758371-A1 | NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013041480-A1 | NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2013-03-28 | — | — | WO | disclosed |