Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 16/20 | 0.54 |
| ▸ | SOAT1 | P35610 | 4/20 | 0.42 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566721 | 0.89 | DGAT1 (0.45) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL4467044 | 0.86 | DGAT1 (0.45) | DGAT1SOAT1CRHR1IDO1 | |
| SCHEMBL4933321 | 0.84 | DGAT1 (0.52) | DGAT1SOAT1CRHR1 | |
| SCHEMBL4941289 | 0.83 | DGAT1 (0.58) | DGAT1SOAT1 | |
| SCHEMBL27790786 | 0.82 | DGAT1 (0.42) | DGAT1SOAT1CRHR1IDO1 | |
| SCHEMBL4566722 | 0.81 | DGAT1 (0.40) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL14813158 | 0.81 | DGAT1 (0.41) | DGAT1SOAT1 | |
| SCHEMBL14813127 | 0.79 | DGAT1 (0.44) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL4490364 | 0.77 | DGAT1 (0.40) | DGAT1SOAT1 | |
| SCHEMBL4935344 | 0.72 | DGAT1 (0.53) | DGAT1SOAT1FAAHCHRM2DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117526-B1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LAB (US) | 2013-04-03 | — | — | EP | disclosed |