Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14815468 | 0.86 | EPHX2 (0.46) | EPHX2TRPV1HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL14815174 | 0.86 | EPHX2 (0.44) | EPHX2CCR6TRPV1HCRTR1HCRTR2 | |
| SCHEMBL14815455 | 0.85 | MGLL (0.49) | HCRTR1HCRTR2CYP2C9 | |
| SCHEMBL14815171 | 0.85 | EPHX2 (0.52) | EPHX2CCR6TRPV1HCRTR1HCRTR2 | |
| SCHEMBL14815549 | 0.84 | EPHX2 (0.41) | EPHX2CCR6TRPV1HCRTR1HCRTR2 | |
| SCHEMBL14815323 | 0.80 | HCRTR2 (0.43) | HCRTR1HCRTR2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14834356 | 0.79 | CCR6 (0.59) | EPHX2CCR6TRPV1HCRTR1NPC1 | |
| SCHEMBL14814682 | 0.77 | HCRTR1 (0.40) | CCR6HCRTR1HCRTR2 | |
| SCHEMBL14815290 | 0.77 | HCRTR1 (0.42) | HCRTR1HCRTR2HSD11B1 | |
| SCHEMBL14815442 | 0.76 | MGLL (0.52) | HSD11B1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130085142-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085142-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | CACNA1C, CACNA1E, CACNA1D | EPHX2 2168/4885CCR6 3966/4885TRPV1 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.