Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11317218 | 0.86 | ACHE (0.48) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5942930 | 0.86 | ACHE (0.69) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL15841393 | 0.84 | ACHE (0.67) | ACHE | |
| SCHEMBL6832195 | 0.84 | ACHE (0.67) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL14005076 | 0.83 | ACHE (0.50) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5942735 | 0.82 | ACHE (0.77) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| Ammonia Solution, Strong SCHEMBL28030602 | 0.82 | ACHE (0.64) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL13703484 | 0.81 | ACHE (0.58) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3902756 | 0.81 | ACHE (0.59) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL31644579 | 0.80 | ACHE (0.74) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2652153-B1 | DNA SEQUENCING BY SYNTHESIS USING MODIFIED NUCLEOTIDES AND NANOPORE DETECTION | UNIV COLUMBIA (US) | 2017-07-05 | — | — | EP | disclosed |
| WO-2013040417-A1 | AMPHIPHILIC CATIONIC POLYMERS FOR THE DELIVERY OF THERAPEUTIC AGENTS | THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A CAROLINAS MEDICAL CENTER (US) | 2013-03-21 | — | — | WO | disclosed |