Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15580648 | 0.92 | RIPK1 (0.32) | RIPK1 | |
| SCHEMBL10120472 | 0.86 | CYP3A4 (0.45) | TMPRSS2RIPK1 | |
| SCHEMBL18293558 | 0.86 | CYP3A4 (0.45) | TMPRSS2RIPK1 | |
| SCHEMBL10142516 | 0.86 | CYP3A4 (0.45) | TMPRSS2RIPK1 | |
| SCHEMBL17452401 | 0.84 | BTN3A1 (0.38) | TMPRSS2RIPK1 | |
| SCHEMBL10142778 | 0.83 | TMPRSS2 (0.34) | TMPRSS2 | |
| SCHEMBL15580717 | 0.81 | RIPK1 (0.32) | TMPRSS2RIPK1 | |
| SCHEMBL15340437 | 0.80 | CYP3A4 (0.39) | TMPRSS2RIPK1 | |
| SCHEMBL10142564 | 0.80 | CYP3A4 (0.39) | TMPRSS2RIPK1 | |
| SCHEMBL14681865 | 0.80 | TMPRSS2 (0.34) | TMPRSS2PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013040492-A2 | METHODS FOR TREATING HCV | GILEAD SCIENCES, INC. (US) | 2013-03-21 | — | — | WO | disclosed |