Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | EEF2K | O00418 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rottlerin SCHEMBL29772022 | 1.00 | KDM4E (1.00) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Rottlerin SCHEMBL29584417 | 1.00 | KDM4E (1.00) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Rottlerin SCHEMBL29900892 | 1.00 | KDM4E (1.00) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Rottlerin SCHEMBL6694400 | 1.00 | KDM4E (1.00) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Rottlerin SCHEMBL1537089 | 1.00 | KDM4E (1.00) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Rottlerin SCHEMBL29928920 | 1.00 | KDM4E (1.00) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| Rottlerin SCHEMBL2524109 | 1.00 | KDM4E (1.00) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL24785845 | 0.92 | KDM4E (0.84) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL29928687 | 0.89 | ALDH1A1 (0.80) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL29929185 | 0.89 | ALDH1A1 (0.80) | KDM4EMEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2116 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3841097-B1 | 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER | BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) | 2026-05-20 | — | — | EP | claimed |
| US-20260124274-A1 | METHODS OF INCREASING READTHROUGH OF A PREMATURE TERMINATION CODON | UNIV RAMOT (IL) | 2026-05-07 | — | — | US | claimed |
| US-20260076961-A1 | COMBINATION TREATMENTS | Celex Oncology Innovations Limited (GB) | 2026-03-19 | — | — | US | claimed |
| US-20250163388-A1 | METHODS FOR DERIVATION AND PROPAGATION OF AVIAN PLURIPOTENT STEM CELLS AND APPLICATIONS THEREOF | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2025-05-22 | — | — | US | claimed |
| US-12268683-B2 | Compounds and methods for synergistic activation of M channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-04-08 | — | — | US | claimed |
| US-20240325335-A1 | BIOLOGICALLY COMPATIBLE, BIOFILM DISRUPTING COMPOSITION AND METHODS | MICHALOW ALEXANDER E (US) | 2024-10-03 | — | — | US | claimed |
| US-20240327520-A1 | METHODS AND COMPOSITIONS FOR PKC-DELTA INHIBITION AND CANCER IMMUNOTHERAPY | THE UNIVERSITY OF CHICAGO (US) | 2024-10-03 | — | — | US | claimed |
| US-20240315965-A1 | COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS | Natural Extraction Systems, LLC (US) | 2024-09-26 | — | — | US | claimed |
| US-20240269192-A1 | FIBROBLAST BASED THERAPEUTICS OF AMYOTROPHIC LATERAL SCLEROSIS | SPINALCYTE LLC (US) | 2024-08-15 | — | — | US | claimed |
| US-20240228552-A9 | NANOPORE TWEEZER APPROACH FOR PROTEIN KINASE ALLOSTERIC DRUG SCREENING | UNIVERSITY OF MASSACHUSETTS | 2024-07-11 | — | — | US | claimed |
| US-20020068271-A1 | Methods for identifying agents capable of modulating protein kinase C theta (PKC0) activity | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY | 2002-06-06 | — | — | US | claimed |
| US-20020048582-A1 | Methods of modulating angiogenesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-04-25 | — | — | US | claimed |
| WO-2002006516-A1 | METHODS OF MODULATING ANGIOGENESIS | JOSLIN DIABETES CENTER, INC. (US) | 2002-01-24 | — | — | WO | claimed |
| WO-2001048236-A1 | METHODS FOR IDENTIFYING AGENTS CAPABLE OF MODULATING PROTEIN KINASE C THETA (PKCυ) ACTIVITY | LA JOLLA INSTITUTE FOR ALLERGY (US) | 2001-07-05 | — | — | WO | claimed |
| WO-2001028543-A1 | TREATMENT OF EOSINOPHIL ASSOCIATED PATHOLOGIES BY MODULATING PKC-δ ACTIVITY | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2001-04-26 | — | — | WO | claimed |
| JP-2001501618-A | — | — | 2001-02-06 | — | — | JP | claimed |
| WO-1999041984-A9 | INTERACTION BETWEEN THE MEC1-DEPENDENT DNA SYNTHESIS CHECKPOINT AND G1 CYCLIN FUNCTION IN $i(SACCAROMYCES CEREVISIAE) | HUTCHINSON FRED CANCER RES (US) | 1999-11-04 | — | — | WO | claimed |
| EP-0949917-A1 | SUBSTANCES AND THEIR USES | Eisai Co., Ltd. (JP) | 1999-10-20 | — | — | EP | claimed |
| WO-1999041984-A1 | INTERACTION BETWEEN THE MEC1-DEPENDENT DNA SYNTHESIS CHECKPOINT AND G1 CYCLIN FUNCTION IN $i(SACCAROMYCES CEREVISIAE) | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 1999-08-26 | — | — | WO | claimed |
| WO-1998014186-A1 | SUBSTANCES AND THEIR USES | EISAI CO., LIMITED (JP) | 1998-04-09 | — | — | WO | claimed |