Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | SUV39H1 | O43463 | 2/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14820079 | 0.87 | CYP1A2 (0.41) | CYP1A2CYP2D6PDGFRBPRKDCLMNA | |
| SCHEMBL18485270 | 0.86 | CYP1A2 (0.43) | CYP1A2CYP2D6DOT1LPRKDCLMNA | |
| SCHEMBL14805698 | 0.86 | CYP1A2 (0.41) | CYP1A2CYP2D6DOT1LPRKDCLMNA | |
| SCHEMBL18485223 | 0.86 | CYP1A2 (0.38) | CYP1A2CYP2D6DOT1LPRKDCLMNA | |
| SCHEMBL14820275 | 0.78 | KIT (0.55) | PDGFRBPRKDCKITGAKPDE10A | |
| SCHEMBL14805745 | 0.77 | CYP1A2 (0.46) | CYP1A2CYP2D6DOT1LPRKDCLMNA | |
| SCHEMBL14820092 | 0.75 | KIT (0.42) | CYP1A2CYP2D6PDGFRBPRKDCKIT | |
| SCHEMBL18484224 | 0.75 | CYP1A2 (0.41) | CYP1A2CYP2D6DOT1LPRKDCLMNA | |
| SCHEMBL18484222 | 0.74 | CYP1A2 (0.39) | CYP1A2CYP2D6PRKDCLMNAHTT | |
| SCHEMBL14805746 | 0.74 | CYP1A2 (0.42) | CYP1A2CYP2D6PRKDCLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170037059-A1 | GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-02-09 | — | — | US | disclosed |
| US-9481675-B2 | Gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20130079323-A1 | GYRASE INHIBITORS | TRIUS THERAPEUTICS, INC. (US) | 2013-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037059-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | CYP1A2 571/4885CYP2D6 263/4885PDGFRB 3757/4885 |
| US-20130079323-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | CYP1A2 571/4885CYP2D6 263/4885PDGFRB 3757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.