Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14821807 | 0.94 | TRPM8 (0.61) | TRPM8ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL14822012 | 0.93 | TRPM8 (0.60) | TRPM8ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL14821832 | 0.89 | TRPM8 (0.57) | TRPM8ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL15276661 | 0.83 | TRPM8 (0.64) | TRPM8ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL14822022 | 0.83 | TRPM8 (0.52) | TRPM8ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL14822021 | 0.83 | TRPM8 (0.52) | TRPM8ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL14822018 | 0.83 | TRPM8 (0.57) | TRPM8ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL14821826 | 0.83 | TRPM8 (0.51) | TRPM8ALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL14822015 | 0.83 | TRPM8 (0.57) | TRPM8ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL14821829 | 0.83 | TRPM8 (0.53) | TRPM8ALDH1A1SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013041621-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 AND USE THEREOF | BASF SE (DE) | 2013-03-28 | — | — | WO | disclosed |