SCHEMBL14822802

SCHEMBL14822802

CC#Cc1ccc2c(c1)C1(c3cc(C#C[Si](C)(C)C)ccc3-2)c2cc(C#C[Si](C)(C)C)ccc2-c2ccc(C#C[Si](C)(C)C)cc21

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 2/20 0.33
CYP1A2 P05177 2/20 0.33
CYP1B1 Q16678 2/20 0.33
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA5 P31644 1/20 0.32
GABRA3 P34903 1/20 0.32
GABRA2 P47869 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL440029 0.93 GABRA1 (0.35) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL6006481 0.85 PDK2 (0.37) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL6005451 0.85 PDK2 (0.37) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL3142132 0.81 MAPT (0.44) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL17791538 0.78 CNR1 (0.32)
SCHEMBL19174201 0.78 CYP1A1 (0.48) CYP1A1CYP1A2CYP1B1GABRA1GABRG2
SCHEMBL17082313 0.75 CYP1A1 (0.49) CYP1A1CYP1A2CYP1B1GABRA1GABRG2
SCHEMBL15450286 0.74 PDK2 (0.36) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL3150471 0.74 ESR1 (0.35)
SCHEMBL12788161 0.73 CYP1A1 (0.33) CYP1A1CYP1A2CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8410185-B2 Porous polymeric materials for hydrogen storage UCHICAGO ARGONNE, LLC (US) 2013-04-02 US disclosed