Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13086263 | 1.00 | POLB (0.39) | POLBTDP1APEX1ALDH1A1FUCA1 | |
| SCHEMBL19325256 | 0.85 | TDP1 (0.46) | POLBTDP1APEX1ALDH1A1FUCA1 | |
| SCHEMBL14495731 | 0.85 | TDP1 (0.46) | POLBTDP1APEX1ALDH1A1FUCA1 | |
| SCHEMBL10016076 | 0.85 | TDP1 (0.46) | POLBTDP1APEX1ALDH1A1FUCA1 | |
| SCHEMBL24120969 | 0.85 | TDP1 (0.46) | POLBTDP1APEX1ALDH1A1FUCA1 | |
| SCHEMBL23612575 | 0.85 | TDP1 (0.46) | POLBTDP1APEX1ALDH1A1FUCA1 | |
| SCHEMBL10195112 | 0.85 | TDP1 (0.46) | POLBTDP1APEX1ALDH1A1FUCA1 | |
| SCHEMBL18053330 | 0.84 | POLB (0.52) | POLBTDP1APEX1FUCA1KMT2A | |
| SCHEMBL6737293 | 0.82 | POLB (0.50) | POLBTDP1APEX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL352543 | 0.82 | POLB (0.50) | POLBTDP1APEX1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410093-B2 | Cycloalkyl substituted pyrimidinediamine compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2013-04-02 | — | — | US | disclosed |