Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 3/20 | 0.71 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.71 |
| ▸ | PAK4 | O96013 | 2/20 | 0.71 |
| ▸ | WEE1 | P30291 | 1/20 | 0.68 |
| ▸ | PAK3 | O75914 | 2/20 | 0.63 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.63 |
| ▸ | CDK4 | P11802 | 8/20 | 0.61 |
| ▸ | CCND1 | P24385 | 8/20 | 0.61 |
| ▸ | CCND2 | P30279 | 7/20 | 0.61 |
| ▸ | CCND3 | P30281 | 7/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1680969 | 0.90 | PAK1 (0.85) | PAK1PKN1PAK4WEE1PAK3 | |
| SCHEMBL13553998 | 0.88 | WEE1 (0.72) | PAK1PKN1PAK4WEE1PAK3 | |
| SCHEMBL14824607 | 0.85 | PAK1 (0.70) | PAK1PKN1PAK4WEE1PAK3 | |
| SCHEMBL659714 | 0.84 | CDK4 (0.72) | PAK1PKN1PAK4WEE1PAK3 | |
| SCHEMBL10192790 | 0.83 | WEE1 (0.77) | PAK1PKN1PAK4WEE1PAK3 | |
| SCHEMBL6808498 | 0.82 | CDK4 (0.74) | PAK1PKN1PAK4WEE1PAK3 | |
| SCHEMBL15030375 | 0.81 | WEE1 (0.71) | PAK1PKN1PAK4WEE1PAK3 | |
| SCHEMBL15036162 | 0.81 | PAK1 (0.69) | PAK1PKN1PAK4WEE1PAK3 | |
| SCHEMBL13553528 | 0.81 | PAK1 (0.69) | PAK1PKN1PAK4WEE1PAK3 | |
| SCHEMBL15035991 | 0.81 | PAK1 (0.69) | PAK1PKN1PAK4WEE1PAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013043232-A2 | 8-ETHYL-6-(ARYL)PYRIDO [2,3-D]PYRIMIDIN-7(8H) -ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER | AFRAXIS, INC. (US) | 2013-03-28 | — | — | WO | disclosed |