Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526525 | 0.83 | GABRA1 (0.48) | GABRA1GABRB2AKR1B1MEN1KMT2A | |
| SCHEMBL249728 | 0.82 | GABRA1 (0.47) | GABRA1GABRB2AKR1B1MEN1KMT2A | |
| SCHEMBL9280279 | 0.79 | GABRA1 (0.66) | GABRA1GABRB2AKR1B1MEN1KMT2A | |
| SCHEMBL28879921 | 0.78 | TAAR1 (0.34) | TAAR1IDO1 | |
| SCHEMBL6335063 | 0.75 | GABRA1 (0.50) | GABRA1GABRB2AKR1B1TAAR1GAA | |
| SCHEMBL839768 | 0.75 | TAAR1 (0.38) | TAAR1IDO1 | |
| SCHEMBL5824091 | 0.74 | GABRA1 (0.58) | GABRA1GABRB2AKR1B1MEN1KMT2A | |
| SCHEMBL29763626 | 0.73 | GABRA1 (0.56) | GABRA1GABRB2AKR1B1MEN1KMT2A | |
| SCHEMBL173300 | 0.73 | GABRA1 (0.56) | GABRA1GABRB2AKR1B1MEN1KMT2A | |
| SCHEMBL283558 | 0.72 | TAAR1 (0.39) | TAAR1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258366-B1 | Quinoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same | KIRIN PHARMA KK (JP) | 2013-04-03 | — | — | EP | disclosed |