Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.52 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HPN | P05981 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14825838 | 0.93 | OPRD1 (0.55) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL14825403 | 0.93 | OPRD1 (0.58) | OPRD1KCNH2ATMMEN1KMT2A | |
| SCHEMBL14825515 | 0.89 | OPRD1 (0.51) | OPRD1KCNH2CYP3A4USP2CYP1A2 | |
| SCHEMBL14825842 | 0.89 | OPRD1 (0.54) | OPRD1KCNH2ATMMEN1KMT2A | |
| SCHEMBL14825477 | 0.88 | CACNA2D1 (0.55) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL14825424 | 0.87 | OPRD1 (0.55) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL14825488 | 0.86 | OPRD1 (0.46) | OPRD1KCNH2OPRM1ATMMEN1 | |
| SCHEMBL14825534 | 0.84 | OPRD1 (0.49) | OPRD1KCNH2ATMMEN1KMT2A | |
| SCHEMBL14825469 | 0.84 | CACNA2D1 (0.53) | CACNA2D1CACNA1BCACNB1CACNA1COPRD1 | |
| SCHEMBL14825362 | 0.83 | OPRD1 (0.48) | CACNA1BOPRD1KCNH2CHRM2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365553-B2 | Heterocyclic compound and H1 receptor antagonist | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2016-06-14 | — | — | US | disclosed |
| US-9365553-B2 | Heterocyclic compound and H1 receptor antagonist | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2016-06-14 | — | — | US | disclosed |
| EP-2578569-B1 | HETEROCYCLIC RING COMPOUND AND H1 RECEPTOR ANTAGONIST | ASKA PHARM CO LTD (JP) | 2015-10-28 | — | — | EP | disclosed |
| EP-2578569-A1 | HETEROCYCLIC RING COMPOUND AND H1 RECEPTOR ANTAGONIST | ASKA Pharmaceutical Co., Ltd. (JP) | 2013-04-10 | — | — | EP | disclosed |
| US-20130085127-A1 | HETEROCYCLIC COMPOUND AND H1 RECEPTOR ANTAGONIST | ASKA PHARMACEUTICAL CO., LTD (JP) | 2013-04-04 | — | — | US | disclosed |
| US-20130085127-A1 | HETEROCYCLIC COMPOUND AND H1 RECEPTOR ANTAGONIST | ASKA PHARMACEUTICAL CO., LTD (JP) | 2013-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085127-A1 | HETEROCYCLIC COMPOUND AND H1 RECEPTOR ANTAGONIST | HRH2, HRH4, HRH1 | CACNA2D1 2370/4885CACNA1B 829/4885CACNB1 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.