SCHEMBL14827705

SCHEMBL14827705

C=C[Si](C)(C)c1cccc(N=C=O)c1

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.38
TRPA1 O75762 1/20 0.38
MAPK1 P28482 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
GABRA1 P14867 1/20 0.33
GABRB2 P47870 1/20 0.33
NR1H2 P55055 1/20 0.32
NR1H3 Q13133 1/20 0.32
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10819194 0.81 CYP3A4 (0.43) CYP3A4TRPA1MAPK1TDP1GABRA1
SCHEMBL10819187 0.80 CYP3A4 (0.42) CYP3A4TRPA1MAPK1TDP1NR1H2
SCHEMBL30448609 0.77 CYP3A4 (0.40) CYP3A4TRPA1MAPK1TDP1GABRA1
SCHEMBL5772639 0.76 NR1H2 (0.42) TDP1NR1H2NR1H3
SCHEMBL10952550 0.75 CYP3A4 (0.39) CYP3A4TRPA1MAPK1TDP1GABRA1
SCHEMBL7628210 0.75 NR1H2 (0.34) NR1H2NR1H3
SCHEMBL10719489 0.74 CYP3A4 (0.38) CYP3A4TRPA1MAPK1TDP1GABRA1
SCHEMBL812212 0.73 CYP3A4 (0.40) CYP3A4TRPA1MAPK1TDP1GABRA1
SCHEMBL7628213 0.73 BRD4 (0.44) TDP1NR1H2NR1H3TSHR
Ethylene SCHEMBL10425506 0.72 TDP1 (0.50) CYP3A4TRPA1MAPK1TDP1GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2452993-B1 THERMOSETTING FLUOROPOLYETHER ADHESIVE COMPOSITION AND ADHESION METHOD SHINETSU CHEMICAL CO (JP) 2016-12-21 EP disclosed
US-9093625-B2 Curable composition for encapsulating optical semiconductor and optical semiconductor apparatus using the same SHIN-ETSU CHEMICAL CO., LTD. (JP) 2015-07-28 US disclosed
US-8860076-B2 Optical semiconductor sealing curable composition and optical semiconductor apparatus using this SHIN-ETSU CHEMICAL CO., LTD. (JP) 2014-10-14 US disclosed
US-8492487-B2 Thermosetting fluoropolyether adhesive composition and adhesion method SHIN-ETSU CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20130082300-A1 OPTICAL SEMICONDUCTOR SEALING CURABLE COMPOSITION AND OPTICAL SEMICONDUCTOR APPARATUS USING THIS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2013-04-04 US disclosed
US-20120123049-A1 THERMOSETTING FLUOROPOLYETHER ADHESIVE COMPOSITION AND ADHESION METHOD SHIN-ETSU CHEMICAL CO., LTD (JP) 2012-05-17 US disclosed