Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | HPD | P32754 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14828547 | 0.84 | KDM4E (0.34) | KMT2AMEN1GPR139KDM4EGAA | |
| SCHEMBL2357893 | 0.82 | MEN1 (0.34) | KMT2AMEN1GPR139KDM4EGAA | |
| SCHEMBL2834258 | 0.81 | KDM4E (0.43) | KMT2AMEN1GPR139KDM4EGAA | |
| SCHEMBL14828543 | 0.81 | F2RL1 (0.41) | KMT2AMEN1KAT2BDHODH | |
| SCHEMBL14828541 | 0.81 | ROCK2 (0.36) | KMT2AMEN1GPR139KDM4EGAA | |
| SCHEMBL14828558 | 0.79 | TTR (0.34) | KMT2AMEN1GPR139KDM4EGAA | |
| SCHEMBL1364883 | 0.77 | CYP2C9 (0.45) | — | |
| SCHEMBL2359567 | 0.75 | — | — | |
| SCHEMBL2830105 | 0.75 | ATM (0.43) | KMT2AMEN1KDM4EGAAKAT2B | |
| SCHEMBL2357787 | 0.73 | F2RL1 (0.39) | KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415373-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-04-09 | — | — | US | claimed |
| US-8415373-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-04-09 | — | — | US | disclosed |